Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2017-11-10 | Columbia (249) | 60 | 75 | Villanova (3) | Final | W | 15 |
| 2 | 2017-11-14 | Nicholls State (294) | 77 | 113 | Villanova (3) | Final | W | 36 |
| 3 | 2017-11-17 | Lafayette (321) | 57 | 104 | Villanova (3) | Final | W | 47 |
| 4 | 2017-11-22 | Western Kentucky (177) | 58 | 66 | Villanova (23) | Final | W | 8 |
| 5 | 2017-11-23 | Tennessee (58) | 76 | 85 | Villanova (23) | Final | W | 9 |
| 6 | 2017-11-24 | Northern Iowa (144) | 50 | 64 | Villanova (23) | Final | W | 14 |
| 7 | 2017-11-29 | Penn (129) | 62 | 90 | Villanova (6) | Final | W | 28 |
| 8 | 2017-12-02 | Villanova (6) | 94 | 53 | Saint Joseph's (195) | Final | W | 41 |
| 9 | 2017-12-05 | Villanova (3) | 88 | 72 | Gonzaga (16) | Final | W | 16 |
| 10 | 2017-12-10 | La Salle (122) | 68 | 77 | Villanova (3) | Final | W | 9 |
| 11 | 2017-12-13 | Villanova (1) | 87 | 67 | Temple (47) | Final | W | 20 |
| 12 | 2017-12-22 | Hofstra (121) | 71 | 95 | Villanova (1) | Final | W | 24 |
| 13 | 2017-12-27 | Villanova (2) | 103 | 85 | DePaul (127) | Final | W | 18 |
| 14 | 2017-12-30 | Villanova (2) | 93 | 101 | Butler (29) | Final | L | -8 |
| 15 | 2018-01-06 | Marquette (51) | 90 | 100 | Villanova (5) | Final | W | 10 |
| 16 | 2018-01-10 | Xavier (9) | 65 | 89 | Villanova (4) | Final | W | 24 |
| 17 | 2018-01-13 | Villanova (4) | 78 | 71 | St. John's (72) | Final | W | 7 |
| 18 | 2018-01-17 | Villanova (1) | 88 | 56 | Georgetown (86) | Final | W | 32 |
| 19 | 2018-01-20 | Villanova (1) | 81 | 61 | Connecticut (94) | Final | W | 20 |
| 20 | 2018-01-23 | Providence (40) | 69 | 89 | Villanova (1) | Final | W | 20 |
| 21 | 2018-01-28 | Villanova (1) | 85 | 82 | Marquette (37) | Final | W | 3 |
| 22 | 2018-02-01 | Creighton (22) | 78 | 98 | Villanova (2) | Final | W | 20 |
| 23 | 2018-02-04 | Seton Hall (26) | 76 | 92 | Villanova (2) | Final | W | 16 |
| 24 | 2018-02-07 | St. John's (89) | 79 | 75 | Villanova (1) | Final | L | -4 |
| 25 | 2018-02-10 | Butler (23) | 75 | 86 | Villanova (1) | Final | W | 11 |
| 26 | 2018-02-14 | Villanova (1) | 71 | 76 | Providence (50) | Final | L | -5 |
| 27 | 2018-02-17 | Villanova (1) | 95 | 79 | Xavier (4) | Final | W | 16 |
| 28 | 2018-02-21 | DePaul (125) | 62 | 93 | Villanova (2) | Final | W | 31 |
| 29 | 2018-02-24 | Villanova (2) | 83 | 89 | Creighton (22) | Final/OT | L | -6 |
| 30 | 2018-02-28 | Villanova (2) | 69 | 68 | Seton Hall (27) | Final/OT | W | 1 |
| 31 | 2018-03-03 | Georgetown (87) | 73 | 97 | Villanova (2) | Final | W | 24 |
| 32 | 2018-03-08 | Marquette (43) | 70 | 94 | Villanova (2) | Final | W | 24 |
| 33 | 2018-03-09 | Butler (32) | 68 | 87 | Villanova (2) | Final | W | 19 |
| 34 | 2018-03-10 | Providence (57) | 66 | 76 | Villanova (2) | Final/OT | W | 10 |
| 35 | 2018-03-17 | Alabama (28) | 58 | 81 | Villanova (7) | Final - 0:00 | W | 23 |
| 36 | 2018-03-23 | West Virginia (67) | 78 | 90 | Villanova (7) | Final - 0:00 | W | 12 |
| 37 | 2018-03-25 | Texas Tech (12) | 59 | 71 | Villanova (7) | Final - 0:00 | W | 12 |
| 38 | 2018-03-31 | Kansas (3) | 79 | 95 | Villanova (7) | Final - 0:00 | W | 16 |
| 39 | 2018-04-02 | Michigan (45) | 62 | 79 | Villanova (7) | Final - 0:00 | W | 17 |