Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-11-07 | Morgan State (291) | 73 | 96 | Xavier (18) | Final | W | 23 |
| 2 | 2022-11-11 | Montana (198) | 64 | 86 | Xavier (18) | Final | W | 22 |
| 3 | 2022-11-15 | Fairfield (252) | 65 | 78 | Xavier (18) | Final | W | 13 |
| 4 | 2022-11-18 | Indiana (19) | 81 | 79 | Xavier (18) | Final | L | -2 |
| 5 | 2022-11-24 | Florida (65) | 83 | 90 | Xavier (18) | Final | W | 7 |
| 6 | 2022-11-25 | Duke (25) | 71 | 64 | Xavier (18) | Final | L | -7 |
| 7 | 2022-11-27 | Xavier (18) | 84 | 88 | Gonzaga (8) | Final | L | -4 |
| 8 | 2022-11-30 | Southeastern Louisiana (318) | 63 | 95 | Xavier (92) | Final | W | 32 |
| 9 | 2022-12-03 | West Virginia (50) | 74 | 84 | Xavier (92) | Final | W | 10 |
| 10 | 2022-12-10 | Xavier (18) | 80 | 77 | Cincinnati (74) | Final | W | 3 |
| 11 | 2022-12-13 | Southern (259) | 59 | 79 | Xavier (92) | Final | W | 20 |
| 12 | 2022-12-16 | Xavier (92) | 102 | 89 | Georgetown (83) | Final | W | 13 |
| 13 | 2022-12-20 | Seton Hall (73) | 70 | 73 | Xavier (18) | Final | W | 3 |
| 14 | 2022-12-28 | Xavier (92) | 84 | 79 | St. John's (12) | Final | W | 5 |
| 15 | 2022-12-31 | Connecticut (13) | 73 | 83 | Xavier (18) | Final | W | 10 |
| 16 | 2023-01-07 | Xavier (18) | 88 | 80 | Villanova (93) | Final | W | 8 |
| 17 | 2023-01-11 | Creighton (21) | 87 | 90 | Xavier (18) | Final | W | 3 |
| 18 | 2023-01-15 | Marquette (14) | 76 | 80 | Xavier (18) | Final | W | 4 |
| 19 | 2023-01-18 | Xavier (18) | 72 | 73 | DePaul (159) | Final | L | -1 |
| 20 | 2023-01-21 | Georgetown (215) | 82 | 95 | Xavier (18) | Final | W | 13 |
| 21 | 2023-01-25 | Xavier (18) | 82 | 79 | Connecticut (13) | Final | W | 3 |
| 22 | 2023-01-28 | Xavier (18) | 67 | 84 | Creighton (21) | Final | L | -17 |
| 23 | 2023-02-01 | Providence (31) | 83 | 85 | Xavier (18) | Final | W | 2 |
| 24 | 2023-02-04 | St. John's (85) | 71 | 96 | Xavier (18) | Final | W | 25 |
| 25 | 2023-02-10 | Xavier (18) | 67 | 69 | Butler (104) | Final | L | -2 |
| 26 | 2023-02-15 | Xavier (92) | 68 | 69 | Marquette (106) | Final | L | -1 |
| 27 | 2023-02-18 | DePaul (95) | 68 | 82 | Xavier (92) | Final | W | 14 |
| 28 | 2023-02-21 | Villanova (93) | 64 | 63 | Xavier (18) | Final | L | -1 |
| 29 | 2023-02-24 | Xavier (18) | 82 | 60 | Seton Hall (73) | Final | W | 22 |
| 30 | 2023-03-01 | Xavier (92) | 94 | 89 | Providence (82) | Final | W | 5 |
| 31 | 2023-03-04 | Butler (80) | 66 | 78 | Xavier (92) | Final | W | 12 |
| 32 | 2023-03-09 | DePaul (154) | 84 | 89 | Xavier (18) | Final | W | 5 |
| 33 | 2023-03-10 | Creighton (27) | 60 | 82 | Xavier (18) | Final | W | 22 |
| 34 | 2023-03-11 | Xavier (18) | 51 | 65 | Marquette (8) | Final | L | -14 |
| 35 | 2023-03-17 | Kennesaw State | 67 | 72 | Xavier | Final | W | 5 |
| 36 | 2023-03-19 | Pittsburgh (52) | 73 | 84 | Xavier (18) | Final | W | 11 |
| 37 | 2023-03-24 | Xavier (18) | 71 | 83 | Texas (7) | Final | L | -12 |