Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-11-07 | Loyola-Maryland (328) | 66 | 72 | DePaul (159) | Final | W | 6 |
| 2 | 2022-11-11 | Western Illinois (240) | 74 | 86 | DePaul (159) | Final | W | 12 |
| 3 | 2022-11-14 | DePaul (159) | 69 | 53 | Minnesota (214) | Final | W | 16 |
| 4 | 2022-11-18 | Santa Clara (56) | 69 | 61 | DePaul (159) | Final | L | -8 |
| 5 | 2022-11-20 | DePaul (159) | 78 | 82 | Oklahoma State (44) | Final | L | -4 |
| 6 | 2022-11-25 | Texas A&M (29) | 82 | 66 | DePaul (159) | Final | L | -16 |
| 7 | 2022-11-30 | Samford (162) | 98 | 103 | DePaul (159) | Final | W | 5 |
| 8 | 2022-12-03 | DePaul (159) | 78 | 72 | Loyola-Chicago (245) | Final | W | 6 |
| 9 | 2022-12-07 | DePaul (159) | 67 | 86 | St. John's (85) | Final | L | -19 |
| 10 | 2022-12-10 | UTEP (195) | 70 | 91 | DePaul (159) | Final | W | 21 |
| 11 | 2022-12-14 | DePaul (159) | 55 | 66 | Duquesne (94) | Final | L | -11 |
| 12 | 2022-12-17 | DePaul (159) | 45 | 83 | Northwestern (24) | Final | L | -38 |
| 13 | 2022-12-25 | DePaul (159) | 65 | 80 | Creighton (21) | Final | L | -15 |
| 14 | 2022-12-29 | Georgetown (215) | 76 | 83 | DePaul (159) | Final | W | 7 |
| 15 | 2023-01-01 | Providence (31) | 74 | 59 | DePaul (159) | Final | L | -15 |
| 16 | 2023-01-04 | DePaul (159) | 70 | 78 | Butler (104) | Final | L | -8 |
| 17 | 2023-01-10 | Villanova (93) | 65 | 75 | DePaul (159) | Final | W | 10 |
| 18 | 2023-01-14 | Seton Hall (73) | 71 | 67 | DePaul (159) | Final | L | -4 |
| 19 | 2023-01-18 | Xavier (18) | 72 | 73 | DePaul (159) | Final | W | 1 |
| 20 | 2023-01-21 | DePaul (159) | 64 | 75 | Providence (31) | Final | L | -11 |
| 21 | 2023-01-24 | DePaul (159) | 76 | 81 | Georgetown (215) | Final | L | -5 |
| 22 | 2023-01-28 | Marquette (14) | 89 | 69 | DePaul (159) | Final | L | -20 |
| 23 | 2023-01-31 | Connecticut (13) | 90 | 76 | DePaul (159) | Final | L | -14 |
| 24 | 2023-02-05 | DePaul (159) | 64 | 69 | Seton Hall (73) | Final | L | -5 |
| 25 | 2023-02-08 | DePaul (159) | 65 | 81 | Villanova (93) | Final | L | -16 |
| 26 | 2023-02-14 | St. John's (85) | 92 | 83 | DePaul (159) | Final | L | -9 |
| 27 | 2023-02-18 | DePaul (159) | 68 | 82 | Xavier (18) | Final | L | -14 |
| 28 | 2023-02-22 | Butler (101) | 59 | 58 | DePaul (164) | Final | L | -1 |
| 29 | 2023-02-25 | DePaul (163) | 84 | 90 | Marquette (13) | Final | L | -6 |
| 30 | 2023-03-01 | DePaul (169) | 59 | 88 | Connecticut (12) | Final | L | -29 |
| 31 | 2023-03-04 | Creighton (30) | 84 | 70 | DePaul (170) | Final | L | -14 |
| 32 | 2023-03-08 | DePaul (156) | 66 | 65 | Seton Hall (80) | Final | W | 1 |
| 33 | 2023-03-09 | DePaul (154) | 84 | 89 | Xavier (18) | Final | L | -5 |