Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-11-07 | La Salle (182) | 68 | 81 | Villanova (93) | Final | W | 13 |
| 2 | 2022-11-11 | Villanova (93) | 64 | 68 | Temple (108) | Final | L | -4 |
| 3 | 2022-11-14 | Delaware State (356) | 50 | 60 | Villanova (93) | Final | W | 10 |
| 4 | 2022-11-18 | Villanova (93) | 71 | 73 | Michigan State (41) | Final | L | -2 |
| 5 | 2022-11-24 | Iowa State (20) | 81 | 79 | Villanova (93) | Final | L | -2 |
| 6 | 2022-11-25 | Portland (177) | 83 | 71 | Villanova (93) | Final | L | -12 |
| 7 | 2022-11-27 | Villanova (93) | 67 | 74 | Oregon (60) | Final | L | -7 |
| 8 | 2022-12-03 | Oklahoma (62) | 66 | 70 | Villanova (93) | Final | W | 4 |
| 9 | 2022-12-07 | Penn (146) | 59 | 70 | Villanova (93) | Final | W | 11 |
| 10 | 2022-12-10 | Boston College (142) | 56 | 77 | Villanova (93) | Final | W | 21 |
| 11 | 2022-12-17 | Villanova (93) | 71 | 64 | Saint Joseph's (170) | Final | W | 7 |
| 12 | 2022-12-21 | St. John's (85) | 63 | 78 | Villanova (93) | Final | W | 15 |
| 13 | 2022-12-28 | Villanova (93) | 66 | 74 | Connecticut (13) | Final | L | -8 |
| 14 | 2022-12-31 | Marquette (14) | 68 | 66 | Villanova (93) | Final | L | -2 |
| 15 | 2023-01-04 | Villanova (93) | 73 | 57 | Georgetown (215) | Final | W | 16 |
| 16 | 2023-01-07 | Xavier (18) | 88 | 80 | Villanova (93) | Final | L | -8 |
| 17 | 2023-01-10 | Villanova (93) | 65 | 75 | DePaul (159) | Final | L | -10 |
| 18 | 2023-01-13 | Villanova (93) | 71 | 79 | Butler (104) | Final | L | -8 |
| 19 | 2023-01-16 | Georgetown (215) | 73 | 77 | Villanova (93) | Final | W | 4 |
| 20 | 2023-01-20 | Villanova (93) | 57 | 49 | St. John's (85) | Final | W | 8 |
| 21 | 2023-01-29 | Providence (31) | 70 | 65 | Villanova (93) | Final | L | -5 |
| 22 | 2023-02-01 | Villanova (93) | 64 | 73 | Marquette (14) | Final | L | -9 |
| 23 | 2023-02-04 | Villanova (93) | 61 | 66 | Creighton (21) | Final | L | -5 |
| 24 | 2023-02-08 | DePaul (159) | 65 | 81 | Villanova (93) | Final | W | 16 |
| 25 | 2023-02-11 | Seton Hall (73) | 54 | 58 | Villanova (93) | Final | W | 4 |
| 26 | 2023-02-14 | Butler (104) | 50 | 62 | Villanova (93) | Final | W | 12 |
| 27 | 2023-02-18 | Villanova (93) | 72 | 85 | Providence (31) | Final | L | -13 |
| 28 | 2023-02-21 | Villanova (93) | 64 | 63 | Xavier (18) | Final | W | 1 |
| 29 | 2023-02-25 | Creighton (33) | 67 | 79 | Villanova (79) | Final | W | 12 |
| 30 | 2023-02-28 | Villanova (75) | 76 | 72 | Seton Hall (79) | Final | W | 4 |
| 31 | 2023-03-04 | Connecticut (8) | 71 | 59 | Villanova (76) | Final | L | -12 |
| 32 | 2023-03-08 | Georgetown (232) | 48 | 80 | Villanova (74) | Final | W | 32 |
| 33 | 2023-03-09 | Villanova (77) | 74 | 87 | Creighton (27) | Final | L | -13 |
| 34 | 2023-03-14 | Villanova | 57 | 62 | Liberty | Final | L | -5 |