Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2024-11-04 | Chicago State (351) | 72 | 79 | Loyola-Chicago (263) | Final | W | 7 |
| 2 | 2024-11-07 | Detroit (212) | 65 | 87 | Loyola-Chicago (263) | Final | W | 22 |
| 3 | 2024-11-10 | Eureka | 53 | 105 | Loyola-Chicago (40) | Final | W | 52 |
| 4 | 2024-11-15 | Loyola-Chicago (29) | 73 | 68 | Princeton (102) | Final | W | 5 |
| 5 | 2024-11-19 | Southern Utah (134) | 72 | 76 | Loyola-Chicago (26) | Final | W | 4 |
| 6 | 2024-11-23 | Tulsa (55) | 53 | 89 | Loyola-Chicago (263) | Final | W | 36 |
| 7 | 2024-12-03 | Eastern Michigan (235) | 54 | 76 | Loyola-Chicago (38) | Final | W | 22 |
| 8 | 2024-12-07 | South Florida (165) | 72 | 74 | Loyola-Chicago (40) | Final | W | 2 |
| 9 | 2024-12-15 | San Francisco (45) | 76 | 66 | Loyola-Chicago (68) | Final | L | -10 |
| 10 | 2024-12-18 | Canisius (362) | 60 | 72 | Loyola-Chicago (77) | Final | W | 12 |
| 11 | 2024-12-22 | Loyola-Chicago (101) | 71 | 72 | Oakland (218) | Final | L | -1 |
| 12 | 2024-12-23 | Charleston (86) | 77 | 68 | Loyola-Chicago (114) | Final | L | -9 |
| 13 | 2024-12-25 | Loyola-Chicago (127) | 68 | 71 | Murray State (146) | Final | L | -3 |
| 14 | 2025-01-04 | Virginia Commonwealth (76) | 84 | 65 | Loyola-Chicago (139) | Final | L | -19 |
| 15 | 2025-01-08 | Loyola-Chicago (120) | 79 | 68 | La Salle (159) | Final | W | 11 |
| 16 | 2025-01-11 | Loyola-Chicago (145) | 57 | 93 | Saint Joseph's (97) | Final | L | -36 |
| 17 | 2025-01-15 | Rhode Island (81) | 77 | 81 | Loyola-Chicago (147) | Final | W | 4 |
| 18 | 2025-01-18 | Loyola-Chicago (130) | 81 | 83 | Dayton (73) | Final (OT) | L | -2 |
| 19 | 2025-01-22 | Fordham (219) | 66 | 70 | Loyola-Chicago (124) | Final | W | 4 |
| 20 | 2025-01-29 | Loyola-Chicago (133) | 53 | 58 | George Mason (68) | Final (OT) | L | -5 |
| 21 | 2025-02-01 | Saint Joseph's (96) | 55 | 58 | Loyola-Chicago (124) | Final | W | 3 |
| 22 | 2025-02-04 | St. Bonaventure (89) | 53 | 77 | Loyola-Chicago (109) | Final | W | 24 |
| 23 | 2025-02-08 | Loyola-Chicago (122) | 56 | 69 | Duquesne (187) | Final | L | -13 |
| 24 | 2025-02-11 | Loyola-Chicago (116) | 87 | 80 | Richmond (257) | Final (OT) | W | 7 |
| 25 | 2025-02-14 | Saint Louis (133) | 69 | 78 | Loyola-Chicago (110) | Final | W | 9 |
| 26 | 2025-02-18 | Loyola-Chicago (107) | 77 | 69 | Davidson (133) | Final | W | 8 |
| 27 | 2025-02-21 | Dayton (76) | 72 | 76 | Loyola-Chicago (101) | Final | W | 4 |
| 28 | 2025-02-26 | George Washington (125) | 57 | 77 | Loyola-Chicago (95) | Final | W | 20 |
| 29 | 2025-03-01 | Loyola-Chicago (263) | 67 | 98 | Saint Louis (31) | Final | L | -31 |
| 30 | 2025-03-05 | Davidson (147) | 72 | 82 | Loyola-Chicago (100) | Final | W | 10 |
| 31 | 2025-03-08 | Loyola-Chicago (96) | 74 | 51 | Massachusetts (203) | Final | W | 23 |
| 32 | 2025-03-14 | Saint Louis (111) | 64 | 72 | Loyola-Chicago (92) | Final | W | 8 |
| 33 | 2025-03-15 | Loyola-Chicago | 55 | 62 | Virginia Commonwealth | Final | L | -7 |
| 34 | 2025-03-19 | Loyola-Chicago (97) | 73 | 70 | San Jose State (177) | Final | W | 3 |
| 35 | 2025-03-23 | Loyola-Chicago (97) | 77 | 76 | San Francisco (55) | Final | W | 1 |
| 36 | 2025-03-26 | Kent State (116) | 62 | 72 | Loyola-Chicago (97) | Final | W | 10 |
| 37 | 2025-04-01 | Chattanooga (104) | 80 | 73 | Loyola-Chicago (97) | Final | L | -7 |