Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2024-11-04 | Southern Indiana (352) | 78 | 80 | DePaul (95) | Final/OT | W | 2 |
| 2 | 2024-11-07 | Prairie View A&M (285) | 59 | 92 | DePaul (95) | Final | W | 33 |
| 3 | 2024-11-11 | Mercer (203) | 64 | 95 | DePaul (18) | Final | W | 31 |
| 4 | 2024-11-15 | Duquesne (327) | 58 | 84 | DePaul (21) | Final | W | 26 |
| 5 | 2024-11-19 | Eastern Illinois (313) | 69 | 78 | DePaul (53) | Final | W | 9 |
| 6 | 2024-11-23 | Northern Illinois (326) | 52 | 98 | DePaul (95) | Final | W | 46 |
| 7 | 2024-11-29 | Valparaiso (178) | 70 | 89 | DePaul (35) | Final | W | 19 |
| 8 | 2024-12-04 | DePaul (64) | 62 | 76 | Texas Tech (39) | Final | L | -14 |
| 9 | 2024-12-10 | Providence (76) | 70 | 63 | DePaul (83) | Final (OT) | L | -7 |
| 10 | 2024-12-14 | Wichita State (67) | 72 | 91 | DePaul (66) | Final | W | 19 |
| 11 | 2024-12-17 | DePaul (80) | 61 | 89 | St. John's (26) | Final | L | -28 |
| 12 | 2024-12-21 | DePaul (91) | 64 | 84 | Northwestern (58) | Final | L | -20 |
| 13 | 2024-12-28 | Loyola-Maryland (252) | 65 | 84 | DePaul (86) | Final | W | 19 |
| 14 | 2025-01-01 | Connecticut (25) | 81 | 68 | DePaul (91) | Final | L | -13 |
| 15 | 2025-01-04 | DePaul (102) | 56 | 100 | Villanova (73) | Final | L | -44 |
| 16 | 2025-01-08 | DePaul (114) | 80 | 85 | Seton Hall (181) | Final (OT) | L | -5 |
| 17 | 2025-01-11 | Xavier (76) | 77 | 63 | DePaul (124) | Final | L | -14 |
| 18 | 2025-01-14 | Marquette (6) | 85 | 83 | DePaul (125) | Final (OT) | L | -2 |
| 19 | 2025-01-17 | DePaul (110) | 73 | 68 | Georgetown (74) | Final | W | 5 |
| 20 | 2025-01-21 | Creighton (36) | 73 | 49 | DePaul (122) | Final | L | -24 |
| 21 | 2025-01-25 | DePaul (134) | 69 | 86 | Butler (96) | Final | L | -17 |
| 22 | 2025-01-29 | DePaul (140) | 61 | 72 | Connecticut (46) | Final | L | -11 |
| 23 | 2025-02-02 | Seton Hall (215) | 57 | 74 | DePaul (135) | Final | W | 17 |
| 24 | 2025-02-05 | Villanova (75) | 59 | 49 | DePaul (142) | Final | L | -10 |
| 25 | 2025-02-11 | DePaul (144) | 58 | 68 | Marquette (25) | Final | L | -10 |
| 26 | 2025-02-15 | DePaul (149) | 68 | 85 | Xavier (57) | Final | L | -17 |
| 27 | 2025-02-19 | St. John's (15) | 82 | 58 | DePaul (150) | Final | L | -24 |
| 28 | 2025-02-22 | Butler (90) | 84 | 72 | DePaul (156) | Final | L | -12 |
| 29 | 2025-02-26 | DePaul (154) | 65 | 75 | Creighton (33) | Final | L | -10 |
| 30 | 2025-03-05 | DePaul (145) | 80 | 77 | Providence (118) | Final | W | 3 |
| 31 | 2025-03-08 | Georgetown (87) | 77 | 83 | DePaul (135) | Final | W | 6 |
| 32 | 2025-03-12 | DePaul (129) | 71 | 67 | Georgetown (93) | Final | W | 4 |
| 33 | 2025-03-13 | DePaul (129) | 81 | 85 | Creighton (38) | Final (2OT) | L | -4 |
| 34 | 2025-04-01 | DePaul (128) | 61 | 83 | Cincinnati (59) | Final | L | -22 |