NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | UTRGV (303) | 56 | 63 | South Florida (15) | Final | L | -7 |
| 2 | 2021-11-14 | UTRGV (303) | 57 | 66 | Texas A&M-Corpus Christi (318) | Final | L | -9 |
| 3 | 2021-11-16 | UTRGV (300) | 58 | 60 | Northern Colorado (326) | Final | L | -2 |
| 4 | 2021-11-21 | McNeese State (215) | 70 | 74 | UTRGV (300) | Final | W | 4 |
| 5 | 2021-11-27 | Southern Utah (340) | 80 | 67 | UTRGV (247) | Final | L | -13 |
| 6 | 2021-12-01 | UTRGV (295) | 44 | 75 | Kansas (27) | Final | L | -31 |
| 7 | 2021-12-06 | Houston Baptist (301) | 58 | 67 | UTRGV (295) | Final | W | 9 |
| 8 | 2021-12-11 | Incarnate Word (265) | 57 | 62 | UTRGV (292) | Final | W | 5 |
| 9 | 2021-12-14 | Texas A&M-Corpus Christi (240) | 43 | 52 | UTRGV (262) | Final | W | 9 |
| 10 | 2021-12-17 | UTSA (281) | 66 | 59 | UTRGV (246) | Final | L | -7 |
| 11 | 2021-12-18 | Liberty (144) | 54 | 32 | UTRGV (192) | Final | L | -22 |
| 12 | 2021-12-30 | Stephen F. Austin (55) | 65 | 50 | UTRGV (263) | Final | L | -15 |
| 13 | 2022-01-01 | Sam Houston State (253) | 0 | 0 | UTRGV (263) | Postponed | - | - |
| 14 | 2022-01-06 | UTRGV (262) | 62 | 50 | Grand Canyon (178) | Final | W | 12 |
| 15 | 2022-01-08 | UTRGV (192) | 0 | 0 | New Mexico State (298) | Postponed | - | - |
| 16 | 2022-01-09 | UTRGV (192) | 58 | 93 | Texas (4) | Final | L | -35 |
| 17 | 2022-01-13 | UTRGV (192) | 58 | 47 | Chicago State (346) | Final | W | 11 |
| 18 | 2022-01-20 | Utah Valley (248) | 59 | 56 | UTRGV (228) | Final | L | -3 |
| 19 | 2022-01-22 | Dixie State (300) | 68 | 75 | UTRGV (228) | Final | W | 7 |
| 20 | 2022-01-24 | Sam Houston State (291) | 66 | 52 | UTRGV (228) | Final | L | -14 |
| 21 | 2022-01-27 | UTRGV (192) | 69 | 88 | Abilene Christian (137) | Final | L | -19 |
| 22 | 2022-01-29 | UTRGV (250) | 64 | 58 | Tarleton State (201) | Final | W | 6 |
| 23 | 2022-01-31 | UTRGV (192) | 51 | 63 | New Mexico State (298) | Final | L | -12 |
| 24 | 2022-02-03 | UTRGV (254) | 39 | 53 | Lamar (194) | Final | L | -14 |
| 25 | 2022-02-05 | Abilene Christian (137) | 62 | 82 | UTRGV (192) | Final | W | 20 |
| 26 | 2022-02-10 | Seattle (343) | 60 | 68 | UTRGV (192) | Final | W | 8 |
| 27 | 2022-02-12 | California Baptist (102) | 94 | 78 | UTRGV (247) | Final | L | -16 |
| 28 | 2022-02-16 | UTRGV (192) | 68 | 71 | Seattle (343) | Final/OT | L | -3 |
| 29 | 2022-02-19 | UTRGV (244) | 49 | 69 | Sam Houston State (237) | Final | L | -20 |
| 30 | 2022-02-24 | Tarleton State (240) | 55 | 64 | UTRGV (255) | Final | W | 9 |
| 31 | 2022-03-03 | Lamar (216) | 69 | 61 | UTRGV (249) | Final | L | -8 |
| 32 | 2022-03-05 | UTRGV (249) | 76 | 74 | Stephen F. Austin (46) | Final | W | 2 |
| 33 | 2022-03-08 | Seattle (268) | 61 | 71 | UTRGV (242) | Final | W | 10 |
| 34 | 2022-03-09 | UTRGV (242) | 73 | 70 | Abilene Christian (198) | Final | W | 3 |
| 35 | 2022-03-10 | UTRGV (242) | 57 | 72 | Utah Valley (200) | Final | L | -15 |