NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-25 | Louisville (13) | 74 | 53 | Southeast Missouri State (243) | Final | L | -21 |
| 2 | 2020-11-28 | Missouri Baptist | 0 | 0 | Southeast Missouri State (243) | Cancelled | - | - |
| 3 | 2020-12-01 | UHSP (108) | 44 | 75 | Southeast Missouri State (243) | Final | W | 31 |
| 4 | 2020-12-06 | Eastern Michigan (202) | 63 | 49 | Southeast Missouri State (243) | Final | L | -14 |
| 5 | 2020-12-11 | Western Illinois (350) | 57 | 67 | Southeast Missouri State (132) | Final | W | 10 |
| 6 | 2020-12-13 | Southeast Missouri State (243) | 51 | 67 | Southern Illinois (291) | Final | L | -16 |
| 7 | 2020-12-18 | Tennessee-Martin (249) | 61 | 58 | Southeast Missouri State (243) | Final | L | -3 |
| 8 | 2020-12-30 | Southeast Missouri State (243) | 79 | 70 | Tennessee Tech (222) | Final | W | 9 |
| 9 | 2021-01-02 | Tennessee State (322) | 50 | 84 | Southeast Missouri State (243) | Final | W | 34 |
| 10 | 2021-01-07 | Southeast Missouri State (243) | 0 | 0 | Belmont (102) | Postponed | - | - |
| 11 | 2021-01-09 | Southeast Missouri State (243) | 64 | 45 | Tennessee State (322) | Final | W | 19 |
| 12 | 2021-01-14 | Murray State (189) | 53 | 69 | Southeast Missouri State (152) | Final | W | 16 |
| 13 | 2021-01-16 | Austin Peay (177) | 61 | 74 | Southeast Missouri State (243) | Final | W | 13 |
| 14 | 2021-01-21 | Southeast Missouri State (243) | 57 | 58 | Morehead State (183) | Final | L | -1 |
| 15 | 2021-01-23 | Southeast Missouri State (243) | 61 | 55 | Eastern Kentucky (111) | Final | W | 6 |
| 16 | 2021-01-28 | SIU-Edwardsville (242) | 62 | 77 | Southeast Missouri State (243) | Final | W | 15 |
| 17 | 2021-01-30 | Eastern Illinois (329) | 51 | 49 | Southeast Missouri State (243) | Final | L | -2 |
| 18 | 2021-02-01 | Southeast Missouri State (116) | 70 | 80 | Tennessee-Martin (64) | Final | L | -10 |
| 19 | 2021-02-04 | Tennessee Tech (222) | 55 | 59 | Southeast Missouri State (243) | Final | W | 4 |
| 20 | 2021-02-06 | Jacksonville State (231) | 54 | 62 | Southeast Missouri State (243) | Final | W | 8 |
| 21 | 2021-02-09 | Southeast Missouri State (145) | 70 | 66 | Belmont (88) | Final | W | 4 |
| 22 | 2021-02-12 | Southeast Missouri State (243) | 79 | 81 | Murray State (52) | Final | L | -2 |
| 23 | 2021-02-13 | Southeast Missouri State (243) | 73 | 68 | Austin Peay (177) | Final/OT | W | 5 |
| 24 | 2021-02-18 | Eastern Kentucky (111) | 82 | 72 | Southeast Missouri State (243) | Final | L | -10 |
| 25 | 2021-02-20 | Morehead State (183) | 52 | 61 | Southeast Missouri State (243) | Final | W | 9 |
| 26 | 2021-02-25 | Southeast Missouri State (243) | 57 | 65 | Eastern Illinois (329) | Final | L | -8 |
| 27 | 2021-02-27 | Southeast Missouri State (243) | 63 | 52 | SIU-Edwardsville (242) | Final | W | 11 |
| 28 | 2021-03-04 | Murray State (152) | 67 | 64 | Southeast Missouri State (135) | Final | L | -3 |