NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-25 | Louisville (13) | 74 | 53 | Southeast Missouri State (243) | Final | W | 21 |
| 2 | 2020-11-28 | Louisville (13) | 0 | 0 | Cincinnati (122) | Cancelled | - | - |
| 3 | 2020-11-29 | Eastern Kentucky (111) | 58 | 101 | Louisville (13) | Final | W | 43 |
| 4 | 2020-12-04 | Louisville (20) | Connecticut (149) | Cancelled | - | - | ||
| 5 | 2020-12-04 | Louisville (13) | 116 | 75 | DePaul (229) | Final | W | 41 |
| 6 | 2020-12-06 | Bellarmine (134) | Louisville (20) | Postponed | - | - | ||
| 7 | 2020-12-06 | Tennessee-Martin (249) | 67 | 85 | Louisville (13) | Final | W | 18 |
| 8 | 2020-12-09 | Louisville (6) | 73 | 49 | Duke (37) | Final | W | 24 |
| 9 | 2020-12-13 | North Carolina (14) | 0 | 0 | Louisville (13) | Postponed | - | - |
| 10 | 2020-12-17 | Florida State (38) | Louisville (5) | Cancelled | - | - | ||
| 11 | 2020-12-20 | Miami (32) | Louisville (5) | Cancelled | - | - | ||
| 12 | 2020-12-31 | Louisville (13) | 0 | 0 | Duke (8) | Cancelled | - | - |
| 13 | 2021-01-01 | North Carolina (35) | Louisville (7) | Postponed | - | - | ||
| 14 | 2021-01-01 | Northern Kentucky (193) | 64 | 74 | Louisville (13) | Final | W | 10 |
| 15 | 2021-01-02 | Bellarmine (358) | 46 | 97 | Louisville (13) | Final | W | 51 |
| 16 | 2021-01-03 | Louisville (13) | 0 | 0 | Virginia (38) | Cancelled | - | - |
| 17 | 2021-01-05 | North Carolina (35) | Louisville (7) | Cancelled | - | - | ||
| 18 | 2021-01-05 | Tennessee-Martin (249) | 61 | 96 | Louisville (13) | Final | W | 35 |
| 19 | 2021-01-07 | Pittsburgh (108) | 0 | 0 | Louisville (8) | Postponed | - | - |
| 20 | 2021-01-07 | Louisville (13) | 71 | 67 | Virginia Tech (39) | Final | W | 4 |
| 21 | 2021-01-10 | Louisville (8) | Florida State (32) | Cancelled | - | - | ||
| 22 | 2021-01-10 | Clemson (47) | 45 | 70 | Louisville (13) | Final | W | 25 |
| 23 | 2021-01-14 | Boston College (60) | 70 | 89 | Louisville (6) | Final | W | 19 |
| 24 | 2021-01-17 | North Carolina State (2) | Louisville (6) | Cancelled | - | - | ||
| 25 | 2021-01-17 | Florida State (129) | 56 | 84 | Louisville (13) | Final | W | 28 |
| 26 | 2021-01-21 | Syracuse (34) | 54 | 67 | Louisville (13) | Final | W | 13 |
| 27 | 2021-01-24 | Louisville (13) | 65 | 63 | Wake Forest (154) | Final | W | 2 |
| 28 | 2021-01-26 | Miami (65) | 76 | 79 | Louisville (3) | Final | W | 3 |
| 29 | 2021-01-28 | Louisville (4) | Virginia Tech (52) | Cancelled | - | - | ||
| 30 | 2021-01-28 | North Carolina (14) | 68 | 79 | Louisville (13) | Final | W | 11 |
| 31 | 2021-02-01 | North Carolina State (2) | 74 | 60 | Louisville (4) | Final | L | -14 |
| 32 | 2021-02-04 | Louisville (13) | 97 | 68 | Boston College (259) | Final | W | 29 |
| 33 | 2021-02-07 | Notre Dame (20) | 65 | 71 | Louisville (13) | Final | W | 6 |
| 34 | 2021-02-11 | Georgia Tech (93) | 70 | 85 | Louisville (13) | Final | W | 15 |
| 35 | 2021-02-14 | Louisville (13) | 0 | 0 | Syracuse (34) | Cancelled | - | - |
| 36 | 2021-02-18 | Louisville (13) | 82 | 58 | Pittsburgh (279) | Final | W | 24 |
| 37 | 2021-02-21 | Clemson (57) | Louisville (3) | Cancelled | - | - | ||
| 38 | 2021-02-21 | Louisville (13) | 59 | 68 | Florida State (129) | Final | L | -9 |
| 39 | 2021-02-28 | Louisville (13) | 78 | 61 | Notre Dame (20) | Final | W | 17 |
| 40 | 2021-03-05 | Wake Forest (154) | 53 | 65 | Louisville (13) | Final | W | 12 |
| 41 | 2021-03-06 | Syracuse (34) | 59 | 72 | Louisville (13) | Final | W | 13 |
| 42 | 2021-03-07 | North Carolina State (8) | 58 | 56 | Louisville (7) | Final | L | -2 |
| 43 | 2021-03-22 | Marist (78) | 43 | 74 | Louisville (8) | Final | W | 31 |
| 44 | 2021-03-24 | Northwestern (38) | 53 | 62 | Louisville (8) | Final | W | 9 |
| 45 | 2021-03-28 | Oregon (33) | 42 | 60 | Louisville (8) | Final | W | 18 |
| 46 | 2021-03-30 | Louisville (8) | 63 | 78 | Stanford (6) | Final | L | -15 |