NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-25 | SIU-Edwardsville (242) | 66 | 50 | Purdue Fort Wayne (148) | Final | W | 16 |
| 2 | 2020-12-02 | SIU-Edwardsville (242) | 73 | 80 | Arkansas State (82) | Final | L | -7 |
| 3 | 2020-12-04 | SIU-Edwardsville (66) | Western Illinois (272) | Cancelled | - | - | ||
| 4 | 2020-12-09 | St. Louis Pharmacy | 44 | 63 | SIU-Edwardsville (246) | Final | W | 19 |
| 5 | 2020-12-12 | UMKC (309) | 89 | 81 | SIU-Edwardsville (242) | Final | L | -8 |
| 6 | 2020-12-18 | SIU-Edwardsville (242) | 58 | 73 | Eastern Illinois (329) | Final | L | -15 |
| 7 | 2020-12-21 | Chicago State (346) | 36 | 62 | SIU-Edwardsville (242) | Final | W | 26 |
| 8 | 2020-12-30 | SIU-Edwardsville (242) | 0 | 0 | Morehead State (183) | Postponed | - | - |
| 9 | 2021-01-02 | Jacksonville State (231) | 0 | 0 | SIU-Edwardsville (242) | Postponed | - | - |
| 10 | 2021-01-07 | Austin Peay (177) | 73 | 54 | SIU-Edwardsville (242) | Final | L | -19 |
| 11 | 2021-01-09 | Murray State (52) | 57 | 64 | SIU-Edwardsville (242) | Final | W | 7 |
| 12 | 2021-01-11 | Eastern Illinois (265) | 77 | 65 | SIU-Edwardsville (292) | Final | L | -12 |
| 13 | 2021-01-14 | Eastern Kentucky (163) | 79 | 63 | SIU-Edwardsville (273) | Final | L | -16 |
| 14 | 2021-01-16 | Morehead State (183) | 63 | 53 | SIU-Edwardsville (242) | Final | L | -10 |
| 15 | 2021-01-19 | SIU-Edwardsville (242) | 47 | 53 | Morehead State (183) | Final | L | -6 |
| 16 | 2021-01-21 | SIU-Edwardsville (242) | 71 | 52 | Tennessee State (322) | Final | W | 19 |
| 17 | 2021-01-23 | SIU-Edwardsville (242) | 57 | 69 | Belmont (102) | Final | L | -12 |
| 18 | 2021-01-28 | SIU-Edwardsville (242) | 62 | 77 | Southeast Missouri State (243) | Final | L | -15 |
| 19 | 2021-01-30 | SIU-Edwardsville (242) | 45 | 79 | Tennessee-Martin (249) | Final | L | -34 |
| 20 | 2021-02-02 | Jacksonville State (231) | 0 | 0 | SIU-Edwardsville (242) | Cancelled | - | - |
| 21 | 2021-02-04 | Tennessee State (322) | 35 | 56 | SIU-Edwardsville (242) | Final | W | 21 |
| 22 | 2021-02-06 | Belmont (102) | 78 | 33 | SIU-Edwardsville (242) | Final | L | -45 |
| 23 | 2021-02-11 | SIU-Edwardsville (242) | 42 | 81 | Tennessee Tech (222) | Final | L | -39 |
| 24 | 2021-02-13 | SIU-Edwardsville (242) | 42 | 86 | Jacksonville State (231) | Final | L | -44 |
| 25 | 2021-02-18 | SIU-Edwardsville (242) | 40 | 66 | Austin Peay (177) | Final | L | -26 |
| 26 | 2021-02-20 | SIU-Edwardsville (242) | 60 | 68 | Murray State (52) | Final | L | -8 |
| 27 | 2021-02-22 | Jacksonville State (231) | 61 | 47 | SIU-Edwardsville (242) | Final | L | -14 |
| 28 | 2021-02-25 | Tennessee-Martin (249) | 68 | 52 | SIU-Edwardsville (242) | Final | L | -16 |
| 29 | 2021-02-27 | Southeast Missouri State (243) | 63 | 52 | SIU-Edwardsville (242) | Final | L | -11 |