NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-25 | Eastern Michigan (202) | 65 | 52 | Southern Illinois (291) | Final | L | -13 |
| 2 | 2020-11-29 | Southern Illinois (291) | 0 | 0 | Memphis (239) | Cancelled | - | - |
| 3 | 2020-12-04 | Western Illinois (272) | Southern Illinois (317) | Cancelled | - | - | ||
| 4 | 2020-12-04 | Southern Illinois (291) | 0 | 0 | Western Illinois (91) | Cancelled | - | - |
| 5 | 2020-12-12 | Austin Peay (177) | 54 | 72 | Southern Illinois (291) | Final | W | 18 |
| 6 | 2020-12-13 | Southeast Missouri State (243) | 51 | 67 | Southern Illinois (291) | Final | W | 16 |
| 7 | 2020-12-15 | Southern Illinois (291) | 0 | 0 | Tennessee-Martin (249) | Cancelled | - | - |
| 8 | 2020-12-17 | UMKC (309) | 68 | 79 | Southern Illinois (291) | Final | W | 11 |
| 9 | 2020-12-20 | Southern Illinois (103) | 43 | 79 | Missouri (151) | Final | L | -36 |
| 10 | 2020-12-22 | Southern Illinois (291) | 0 | 0 | Illinois (29) | Cancelled | - | - |
| 11 | 2021-01-01 | Southern Illinois (124) | Indiana State (199) | Cancelled | - | - | ||
| 12 | 2021-01-01 | Evansville (272) | 41 | 59 | Southern Illinois (291) | Final | W | 18 |
| 13 | 2021-01-02 | Evansville (272) | 51 | 69 | Southern Illinois (291) | Final | W | 18 |
| 14 | 2021-01-03 | Southern Illinois (124) | Evansville (203) | Cancelled | - | - | ||
| 15 | 2021-01-08 | Bradley (139) | Southern Illinois (92) | Cancelled | - | - | ||
| 16 | 2021-01-08 | Southern Illinois (291) | 55 | 77 | Bradley (155) | Final | L | -22 |
| 17 | 2021-01-09 | Southern Illinois (291) | 68 | 80 | Bradley (155) | Final | L | -12 |
| 18 | 2021-01-10 | Illinois State (132) | Southern Illinois (92) | Cancelled | - | - | ||
| 19 | 2021-01-15 | Southern Illinois (158) | Loyola-Chicago (201) | Cancelled | - | - | ||
| 20 | 2021-01-17 | Southern Illinois (158) | Valparaiso (135) | Cancelled | - | - | ||
| 21 | 2021-01-22 | Drake (94) | Southern Illinois (154) | Cancelled | - | - | ||
| 22 | 2021-01-24 | Northern Iowa (91) | Southern Illinois (154) | Cancelled | - | - | ||
| 23 | 2021-01-27 | Southern Illinois (291) | 44 | 61 | Missouri State (110) | Final | L | -17 |
| 24 | 2021-01-29 | Southern Illinois (154) | Missouri State (22) | Cancelled | - | - | ||
| 25 | 2021-01-30 | Southern Illinois (291) | 46 | 53 | Loyola-Chicago (175) | Final | L | -7 |
| 26 | 2021-01-31 | Southern Illinois (291) | 46 | 55 | Loyola-Chicago (175) | Final | L | -9 |
| 27 | 2021-02-05 | Southern Illinois (184) | Illinois State (101) | Cancelled | - | - | ||
| 28 | 2021-02-05 | Illinois State (136) | 57 | 50 | Southern Illinois (291) | Final | L | -7 |
| 29 | 2021-02-06 | Illinois State (136) | 41 | 43 | Southern Illinois (291) | Final | W | 2 |
| 30 | 2021-02-07 | Southern Illinois (184) | Bradley (102) | Cancelled | - | - | ||
| 31 | 2021-02-11 | Southern Illinois (291) | 70 | 74 | Drake (236) | Final | L | -4 |
| 32 | 2021-02-12 | Valparaiso (158) | Southern Illinois (176) | Cancelled | - | - | ||
| 33 | 2021-02-12 | Southern Illinois (291) | 54 | 83 | Drake (236) | Final | L | -29 |
| 34 | 2021-02-14 | Loyola-Chicago (166) | Southern Illinois (176) | Cancelled | - | - | ||
| 35 | 2021-02-19 | Southern Illinois (176) | Northern Iowa (93) | Cancelled | - | - | ||
| 36 | 2021-02-19 | Southern Illinois (291) | 84 | 69 | Indiana State (285) | Final | W | 15 |
| 37 | 2021-02-20 | Southern Illinois (291) | 76 | 52 | Indiana State (285) | Final | W | 24 |
| 38 | 2021-02-21 | Southern Illinois (176) | Drake (82) | Cancelled | - | - | ||
| 39 | 2021-02-24 | Missouri State (110) | 67 | 55 | Southern Illinois (291) | Final | L | -12 |
| 40 | 2021-02-26 | Missouri State (21) | Southern Illinois (176) | Cancelled | - | - | ||
| 41 | 2021-02-27 | Valparaiso (360) | 75 | 64 | Southern Illinois (291) | Final | L | -11 |
| 42 | 2021-02-28 | Valparaiso (360) | 70 | 63 | Southern Illinois (291) | Final/OT | L | -7 |
| 43 | 2021-03-04 | Evansville (271) | Southern Illinois (176) | Cancelled | - | - | ||
| 44 | 2021-03-05 | Northern Iowa (132) | 67 | 56 | Southern Illinois (291) | Final | L | -11 |
| 45 | 2021-03-06 | Indiana State (269) | Southern Illinois (176) | Cancelled | - | - | ||
| 46 | 2021-03-06 | Northern Iowa (132) | 64 | 41 | Southern Illinois (291) | Final | L | -23 |
| 47 | 2021-03-11 | Indiana State (277) | 89 | 90 | Southern Illinois (200) | Final/OT | W | 1 |
| 48 | 2021-03-12 | Southern Illinois (200) | 59 | 70 | Missouri State (12) | Final | L | -11 |