NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-27 | Notre Dame (20) | 85 | 86 | Ohio (163) | Final | L | -1 |
| 2 | 2020-11-29 | Miami (OH) (74) | 68 | 88 | Notre Dame (20) | Final | W | 20 |
| 3 | 2020-12-03 | Michigan (6) | 76 | 66 | Notre Dame (20) | Final | L | -10 |
| 4 | 2020-12-06 | IU-Indy (247) | 58 | 65 | Notre Dame (20) | Final | W | 7 |
| 5 | 2020-12-13 | Georgia Tech (93) | 82 | 67 | Notre Dame (20) | Final | L | -15 |
| 6 | 2020-12-17 | Virginia Tech (39) | 78 | 84 | Notre Dame (20) | Final | W | 6 |
| 7 | 2020-12-20 | Notre Dame (102) | 55 | 78 | Clemson (29) | Final | L | -23 |
| 8 | 2020-12-31 | Notre Dame (20) | 71 | 60 | Miami (64) | Final | W | 11 |
| 9 | 2021-01-03 | Georgia Tech (93) | 67 | 69 | Notre Dame (20) | Final | W | 2 |
| 10 | 2021-01-07 | Notre Dame (20) | 61 | 64 | Boston College (259) | Final | L | -3 |
| 11 | 2021-01-10 | Notre Dame (20) | 0 | 0 | Syracuse (34) | Postponed | - | - |
| 12 | 2021-01-14 | Pittsburgh (115) | Notre Dame (65) | Postponed | - | - | ||
| 13 | 2021-01-14 | Wake Forest (33) | 72 | 79 | Notre Dame (65) | Final | W | 7 |
| 14 | 2021-01-17 | Boston College (259) | 73 | 83 | Notre Dame (20) | Final | W | 10 |
| 15 | 2021-01-21 | Notre Dame (20) | 65 | 60 | Virginia Tech (39) | Final | W | 5 |
| 16 | 2021-01-24 | Notre Dame (20) | 73 | 78 | North Carolina (14) | Final | L | -5 |
| 17 | 2021-01-31 | Duke (65) | Notre Dame (47) | Cancelled | - | - | ||
| 18 | 2021-01-31 | Notre Dame (20) | 69 | 81 | Syracuse (34) | Final | L | -12 |
| 19 | 2021-02-07 | Notre Dame (20) | 65 | 71 | Louisville (13) | Final | L | -6 |
| 20 | 2021-02-11 | Virginia (38) | 0 | 0 | Notre Dame (20) | Cancelled | - | - |
| 21 | 2021-02-15 | Notre Dame (20) | 0 | 0 | North Carolina State (27) | Cancelled | - | - |
| 22 | 2021-02-18 | Syracuse (34) | 0 | 0 | Notre Dame (20) | Cancelled | - | - |
| 23 | 2021-02-22 | Notre Dame (20) | 59 | 48 | Pittsburgh (279) | Final | W | 11 |
| 24 | 2021-02-25 | Florida State (129) | 64 | 72 | Notre Dame (20) | Final | W | 8 |
| 25 | 2021-02-28 | Louisville (13) | 78 | 61 | Notre Dame (20) | Final | L | -17 |
| 26 | 2021-03-04 | Clemson (79) | 68 | 63 | Notre Dame (53) | Final | L | -5 |