Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2017-09-02 | Louisville (13) | 35 | Purdue (114) | 28 | Final | L | -7 |
| 2 | 2017-09-08 | Ohio (82) | 21 | Purdue (114) | 44 | Final | W | 23 |
| 3 | 2017-09-16 | Purdue (114) | 35 | Missouri (76) | 3 | Final | W | 32 |
| 4 | 2017-09-23 | Michigan (5) | 28 | Purdue (114) | 10 | Final | L | -18 |
| 5 | 2017-10-07 | Minnesota (31) | 17 | Purdue (63) | 31 | Final | W | 14 |
| 6 | 2017-10-14 | Purdue (60) | 9 | Wisconsin (9) | 17 | Final | L | -8 |
| 7 | 2017-10-21 | Purdue (47) | 12 | Rutgers (98) | 14 | Final | L | -2 |
| 8 | 2017-10-28 | Nebraska (69) | 25 | Purdue (57) | 24 | Final | L | -1 |
| 9 | 2017-11-04 | Illinois (109) | 10 | Purdue (63) | 29 | Final | W | 19 |
| 10 | 2017-11-11 | Purdue (49) | 13 | Northwestern (27) | 23 | Final | L | -10 |
| 11 | 2017-11-18 | Purdue (57) | 24 | Iowa (20) | 15 | Final | W | 9 |
| 12 | 2017-11-25 | Indiana (61) | 24 | Purdue (48) | 31 | Final | W | 7 |
| 13 | 2017-12-27 | Arizona (57) | 35 | Purdue (45) | 38 | Final | W | 3 |