Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2017-09-02 | Louisville (13) | 35 | Purdue (114) | 28 | Final | W | 7 |
| 2 | 2017-09-09 | Louisville (13) | 47 | North Carolina (41) | 35 | Final | W | 12 |
| 3 | 2017-09-16 | Clemson (2) | 47 | Louisville (13) | 21 | Final | L | -26 |
| 4 | 2017-09-23 | Kent State (140) | 3 | Louisville (13) | 42 | Final | W | 39 |
| 5 | 2017-09-30 | Murray State (224) | 10 | Louisville (43) | 55 | Final | W | 45 |
| 6 | 2017-10-05 | Louisville | 25 | North Carolina State | 39 | Final | L | -14 |
| 7 | 2017-10-14 | Boston College (70) | 45 | Louisville (64) | 42 | Final | L | -3 |
| 8 | 2017-10-21 | Louisville (61) | 31 | Florida State (37) | 28 | Final | W | 3 |
| 9 | 2017-10-28 | Louisville (49) | 32 | Wake Forest (43) | 42 | Final | L | -10 |
| 10 | 2017-11-11 | Virginia (64) | 21 | Louisville (57) | 38 | Final | W | 17 |
| 11 | 2017-11-18 | Syracuse (64) | 10 | Louisville (48) | 56 | Final | W | 46 |
| 12 | 2017-11-25 | Louisville (37) | 44 | Kentucky (50) | 17 | Final | W | 27 |
| 13 | 2017-12-30 | Louisville | 27 | Mississippi State | 31 | Final | L | -4 |