Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2015-09-05 | Louisville (24) | 24 | Auburn (13) | 31 | Final | L | -7 |
| 2 | 2015-09-12 | Houston (78) | 34 | Louisville (24) | 31 | Final | L | -3 |
| 3 | 2015-09-17 | Clemson (27) | 20 | Louisville (114) | 17 | Final | L | -3 |
| 4 | 2015-09-26 | Samford | 3 | Louisville | 45 | Final | W | 42 |
| 5 | 2015-10-03 | Louisville | 20 | North Carolina State | 13 | Final | W | 7 |
| 6 | 2015-10-17 | Louisville (66) | 21 | Florida State (15) | 41 | Final | L | -20 |
| 7 | 2015-10-24 | Boston College (76) | 14 | Louisville (65) | 17 | Final | W | 3 |
| 8 | 2015-10-30 | Louisville (51) | 20 | Wake Forest (87) | 19 | Final | W | 1 |
| 9 | 2015-11-07 | Syracuse (74) | 17 | Louisville (47) | 41 | Final | W | 24 |
| 10 | 2015-11-14 | Virginia (87) | 31 | Louisville (42) | 38 | Final | W | 7 |
| 11 | 2015-11-21 | Louisville | 34 | Pittsburgh | 45 | Final | L | -11 |
| 12 | 2015-11-28 | Louisville (47) | 38 | Kentucky (68) | 24 | Final | W | 14 |
| 13 | 2015-12-30 | Texas A&M (33) | 21 | Louisville (44) | 27 | Final | W | 6 |