Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2015-09-03 | Duke (37) | 37 | Tulane (107) | 7 | Final | W | 30 |
| 2 | 2015-09-12 | North Carolina Central | 0 | Duke | 55 | Final | W | 55 |
| 3 | 2015-09-19 | Northwestern (28) | 19 | Duke (33) | 10 | Final | L | -9 |
| 4 | 2015-09-26 | Georgia Tech (39) | 20 | Duke (46) | 34 | Final | W | 14 |
| 5 | 2015-10-03 | Boston College (47) | 7 | Duke (34) | 9 | Final | W | 2 |
| 6 | 2015-10-10 | Duke (26) | 44 | Army (118) | 3 | Final | W | 41 |
| 7 | 2015-10-24 | Duke (29) | 45 | Virginia Tech (67) | 43 | Final/4OT | W | 2 |
| 8 | 2015-10-31 | Miami | 30 | Duke | 27 | Final | L | -3 |
| 9 | 2015-11-07 | Duke (37) | 31 | North Carolina (26) | 66 | Final | L | -35 |
| 10 | 2015-11-14 | Pittsburgh | 31 | Duke | 13 | Final | L | -18 |
| 11 | 2015-11-21 | Duke (50) | 34 | Virginia (94) | 42 | Final | L | -8 |
| 12 | 2015-11-28 | Duke (65) | 27 | Wake Forest (90) | 21 | Final | W | 6 |
| 13 | 2015-12-26 | Indiana (52) | 41 | Duke (61) | 44 | Final/OT | W | 3 |