Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2017-09-02 | Kent State (140) | 3 | Clemson (2) | 56 | Final | W | 53 |
| 2 | 2017-09-09 | Auburn (14) | 6 | Clemson (2) | 14 | Final | W | 8 |
| 3 | 2017-09-16 | Clemson (2) | 47 | Louisville (13) | 21 | Final | W | 26 |
| 4 | 2017-09-23 | Boston College (67) | 7 | Clemson (2) | 34 | Final | W | 27 |
| 5 | 2017-09-30 | Clemson (2) | 31 | Virginia Tech (11) | 17 | Final | W | 14 |
| 6 | 2017-10-07 | Wake Forest (27) | 14 | Clemson (1) | 28 | Final | W | 14 |
| 7 | 2017-10-13 | Clemson (1) | 24 | Syracuse (84) | 27 | Final | L | -3 |
| 8 | 2017-10-28 | Georgia Tech (42) | 10 | Clemson (9) | 24 | Final | W | 14 |
| 9 | 2017-11-04 | Clemson | 38 | North Carolina State | 31 | Final | W | 7 |
| 10 | 2017-11-11 | Florida State (59) | 14 | Clemson (7) | 31 | Final | W | 17 |
| 11 | 2017-11-18 | The Citadel (196) | 3 | Clemson (6) | 61 | Final | W | 58 |
| 12 | 2017-11-25 | Clemson (6) | 34 | South Carolina (33) | 10 | Final | W | 24 |
| 13 | 2017-12-02 | Miami (11) | 3 | Clemson (4) | 38 | Final | W | 35 |
| 14 | 2018-01-01 | Alabama (4) | 24 | Clemson (2) | 6 | Final | L | -18 |