Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2015-09-05 | Wofford | 10 | Clemson | 49 | Final | W | 39 |
| 2 | 2015-09-12 | Appalachian State (94) | 10 | Clemson (21) | 41 | Final | W | 31 |
| 3 | 2015-09-17 | Clemson (27) | 20 | Louisville (114) | 17 | Final | W | 3 |
| 4 | 2015-10-03 | Notre Dame (12) | 22 | Clemson (22) | 24 | Final | W | 2 |
| 5 | 2015-10-10 | Georgia Tech (67) | 24 | Clemson (9) | 43 | Final | W | 19 |
| 6 | 2015-10-17 | Boston College (70) | 17 | Clemson (5) | 34 | Final | W | 17 |
| 7 | 2015-10-24 | Clemson | 58 | Miami | 0 | Final | W | 58 |
| 8 | 2015-10-31 | Clemson | 56 | North Carolina State | 41 | Final | W | 15 |
| 9 | 2015-11-07 | Florida State (22) | 13 | Clemson (1) | 23 | Final | W | 10 |
| 10 | 2015-11-14 | Clemson (1) | 37 | Syracuse (75) | 27 | Final | W | 10 |
| 11 | 2015-11-21 | Wake Forest (88) | 13 | Clemson (1) | 33 | Final | W | 20 |
| 12 | 2015-11-28 | Clemson (1) | 37 | South Carolina (93) | 32 | Final | W | 5 |
| 13 | 2015-12-05 | North Carolina (11) | 37 | Clemson (1) | 45 | Final | W | 8 |
| 14 | 2015-12-31 | Oklahoma (5) | 17 | Clemson (1) | 37 | Final | W | 20 |
| 15 | 2016-01-11 | Alabama (2) | 45 | Clemson (1) | 40 | Final | L | -5 |