Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2015-09-05 | Tennessee Tech | 24 | Houston | 52 | Final | W | 28 |
| 2 | 2015-09-12 | Houston (78) | 34 | Louisville (24) | 31 | Final | W | 3 |
| 3 | 2015-09-26 | Texas State (102) | 14 | Houston (49) | 59 | Final | W | 45 |
| 4 | 2015-10-03 | Houston (36) | 38 | Tulsa (49) | 24 | Final | W | 14 |
| 5 | 2015-10-08 | SMU (121) | 28 | Houston (23) | 49 | Final | W | 21 |
| 6 | 2015-10-16 | Houston (25) | 42 | Tulane (112) | 7 | Final | W | 35 |
| 7 | 2015-10-24 | Houston | 59 | Central Florida | 10 | Final | W | 49 |
| 8 | 2015-10-31 | Vanderbilt (77) | 0 | Houston (20) | 34 | Final | W | 34 |
| 9 | 2015-11-07 | Cincinnati (43) | 30 | Houston (17) | 33 | Final | W | 3 |
| 10 | 2015-11-14 | Memphis (13) | 34 | Houston (12) | 35 | Final | W | 1 |
| 11 | 2015-11-21 | Houston | 17 | Connecticut | 20 | Final | L | -3 |
| 12 | 2015-11-27 | Navy (12) | 31 | Houston (18) | 52 | Final | W | 21 |
| 13 | 2015-12-05 | Temple (24) | 13 | Houston (13) | 24 | Final | W | 11 |
| 14 | 2015-12-31 | Houston (10) | 38 | Florida State (12) | 24 | Final | W | 14 |