Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2015-09-12 | Massachusetts (120) | 14 | Colorado (96) | 48 | Final | L | -34 |
| 2 | 2015-09-19 | Temple | 25 | Massachusetts | 23 | Final | L | -2 |
| 3 | 2015-09-26 | Massachusetts | 27 | Notre Dame | 62 | Final | L | -35 |
| 4 | 2015-10-03 | Florida International | 14 | Massachusetts | 24 | Final | W | 10 |
| 5 | 2015-10-10 | Massachusetts | 38 | Bowling Green | 62 | Final | L | -24 |
| 6 | 2015-10-17 | Kent State | 15 | Massachusetts | 10 | Final | L | -5 |
| 7 | 2015-10-24 | Toledo | 51 | Massachusetts | 35 | Final | L | -16 |
| 8 | 2015-10-31 | Massachusetts | 10 | Ball State | 20 | Final | L | -10 |
| 9 | 2015-11-07 | Akron | 17 | Massachusetts | 13 | Final | L | -4 |
| 10 | 2015-11-14 | Massachusetts | 28 | Eastern Michigan | 17 | Final | W | 11 |
| 11 | 2015-11-21 | Miami (OH) | 20 | Massachusetts | 13 | Final | L | -7 |
| 12 | 2015-11-27 | Massachusetts | 31 | Buffalo | 26 | Final | W | 5 |