Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-25 | Old Dominion (254) | 67 | 85 | Maryland (114) | Final | L | -18 |
| 2 | 2020-11-28 | William & Mary (141) | 78 | 86 | Old Dominion (254) | Final | W | 8 |
| 3 | 2020-12-02 | Old Dominion (254) | 80 | 66 | Norfolk State (322) | Final | W | 14 |
| 4 | 2020-12-07 | Old Dominion (254) | 0 | 0 | James Madison (202) | Cancelled | - | - |
| 5 | 2020-12-07 | Old Dominion (114) | James Madison (133) | Cancelled | - | - | ||
| 6 | 2020-12-12 | Old Dominion (254) | 54 | 77 | Virginia Commonwealth (38) | Final | L | -23 |
| 7 | 2020-12-13 | Old Dominion (63) | George Mason (310) | Cancelled | - | - | ||
| 8 | 2020-12-20 | Northeastern (300) | 62 | 66 | Old Dominion (254) | Final | W | 4 |
| 9 | 2020-12-22 | Virginia Wesleyan | 57 | 77 | Old Dominion (254) | Final | W | 20 |
| 10 | 2021-01-01 | Old Dominion (254) | 67 | 82 | Florida International (214) | Final | L | -15 |
| 11 | 2021-01-02 | Old Dominion (254) | 71 | 66 | Florida International (214) | Final | W | 5 |
| 12 | 2021-01-08 | Florida Atlantic (128) | 67 | 71 | Old Dominion (254) | Final | W | 4 |
| 13 | 2021-01-09 | Florida Atlantic (128) | 55 | 64 | Old Dominion (254) | Final | W | 9 |
| 14 | 2021-01-15 | Old Dominion (254) | 59 | 69 | Rice (228) | Final | L | -10 |
| 15 | 2021-01-16 | Old Dominion (254) | 61 | 58 | Rice (228) | Final | W | 3 |
| 16 | 2021-01-22 | North Texas (125) | 0 | 0 | Old Dominion (254) | Cancelled | - | - |
| 17 | 2021-01-23 | North Texas (125) | 0 | 0 | Old Dominion (254) | Cancelled | - | - |
| 18 | 2021-01-29 | Old Dominion (254) | 0 | 0 | Western Kentucky (154) | Postponed | - | - |
| 19 | 2021-01-30 | Old Dominion (254) | 0 | 0 | Western Kentucky (154) | Postponed | - | - |
| 20 | 2021-02-05 | Marshall (155) | 81 | 82 | Old Dominion (254) | Final | W | 1 |
| 21 | 2021-02-06 | Marshall (155) | 87 | 67 | Old Dominion (254) | Final | L | -20 |
| 22 | 2021-02-10 | Old Dominion (254) | 78 | 76 | Charlotte (173) | Final/OT | W | 2 |
| 23 | 2021-02-13 | Charlotte (173) | 45 | 64 | Old Dominion (254) | Final | W | 19 |
| 24 | 2021-02-19 | Old Dominion (254) | 69 | 76 | UAB (115) | Final | L | -7 |
| 25 | 2021-02-20 | Old Dominion (254) | 65 | 58 | UAB (115) | Final | W | 7 |
| 26 | 2021-02-26 | Middle Tennessee (164) | 61 | 67 | Old Dominion (254) | Final | W | 6 |
| 27 | 2021-02-27 | Middle Tennessee (164) | 60 | 73 | Old Dominion (254) | Final | W | 13 |
| 28 | 2021-03-05 | Old Dominion (254) | 71 | 69 | Western Kentucky (154) | Final | W | 2 |
| 29 | 2021-03-06 | Old Dominion (254) | 57 | 60 | Western Kentucky (154) | Final | L | -3 |
| 30 | 2021-03-11 | North Texas (125) | 61 | 55 | Old Dominion (254) | Final | L | -6 |