Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-25 | Lancaster Bible | James Madison (292) | Cancelled | - | - | ||
| 2 | 2020-11-25 | Limestone | 55 | 89 | James Madison (202) | Final | W | 34 |
| 3 | 2020-11-27 | Norfolk State (322) | 83 | 73 | James Madison (202) | Final | L | -10 |
| 4 | 2020-11-29 | Radford (255) | 59 | 67 | James Madison (202) | Final | W | 8 |
| 5 | 2020-12-05 | Maryland (114) | 0 | 0 | James Madison (202) | Cancelled | - | - |
| 6 | 2020-12-07 | Old Dominion (254) | 0 | 0 | James Madison (202) | Cancelled | - | - |
| 7 | 2020-12-07 | Old Dominion (114) | James Madison (133) | Cancelled | - | - | ||
| 8 | 2020-12-09 | Carolina University | James Madison (234) | Cancelled | - | - | ||
| 9 | 2020-12-12 | James Madison (202) | 0 | 0 | George Mason (86) | Cancelled | - | - |
| 10 | 2020-12-12 | James Madison (234) | George Mason (310) | Cancelled | - | - | ||
| 11 | 2020-12-19 | James Madison (202) | 64 | 73 | East Carolina (252) | Final | L | -9 |
| 12 | 2020-12-20 | Alice Lloyd | 55 | 98 | James Madison (202) | Final | W | 43 |
| 13 | 2020-12-22 | James Madison (221) | 0 | 0 | Florida (48) | Cancelled | - | - |
| 14 | 2020-12-22 | James Madison (202) | 81 | 82 | Virginia Commonwealth (38) | Final | L | -1 |
| 15 | 2021-01-03 | James Madison (215) | 0 | 0 | Towson (313) | Cancelled | - | - |
| 16 | 2021-01-03 | Morgan State (337) | 80 | 73 | James Madison (202) | Final | L | -7 |
| 17 | 2021-01-05 | Florida Atlantic (128) | 70 | 79 | James Madison (202) | Final | W | 9 |
| 18 | 2021-01-09 | James Madison (202) | 0 | 0 | UNC-Wilmington (90) | Cancelled | - | - |
| 19 | 2021-01-09 | Elon (272) | 0 | 0 | James Madison (249) | Cancelled | - | - |
| 20 | 2021-01-10 | James Madison (249) | 0 | 0 | UNC-Wilmington (134) | Cancelled | - | - |
| 21 | 2021-01-10 | Elon (272) | 0 | 0 | James Madison (249) | Cancelled | - | - |
| 22 | 2021-01-10 | Chowan | 76 | 100 | James Madison (202) | Final | W | 24 |
| 23 | 2021-01-16 | James Madison (202) | 81 | 72 | Towson (152) | Final | W | 9 |
| 24 | 2021-01-23 | James Madison (202) | 63 | 72 | Northeastern (300) | Final | L | -9 |
| 25 | 2021-01-24 | James Madison (202) | 79 | 72 | Northeastern (300) | Final | W | 7 |
| 26 | 2021-01-27 | Towson (152) | 63 | 78 | James Madison (202) | Final | W | 15 |
| 27 | 2021-01-30 | Charleston (123) | 0 | 0 | James Madison (202) | Cancelled | - | - |
| 28 | 2021-01-31 | Charleston (239) | 0 | 0 | James Madison (161) | Cancelled | - | - |
| 29 | 2021-01-31 | Drexel (215) | 64 | 73 | James Madison (202) | Final | W | 9 |
| 30 | 2021-02-03 | Elon (232) | 57 | 78 | James Madison (202) | Final | W | 21 |
| 31 | 2021-02-06 | James Madison (202) | 0 | 0 | William & Mary (141) | Postponed | - | - |
| 32 | 2021-02-07 | James Madison (202) | 0 | 0 | William & Mary (141) | Cancelled | - | - |
| 33 | 2021-02-09 | James Madison (152) | 0 | 0 | UNC-Wilmington (231) | Cancelled | - | - |
| 34 | 2021-02-09 | James Madison (202) | 70 | 61 | Elon (232) | Final | W | 9 |
| 35 | 2021-02-10 | James Madison (152) | 0 | 0 | UNC-Wilmington (231) | Cancelled | - | - |
| 36 | 2021-02-13 | Hofstra (98) | 89 | 93 | James Madison (202) | Final | W | 4 |
| 37 | 2021-02-14 | Hofstra (98) | 70 | 74 | James Madison (202) | Final | W | 4 |
| 38 | 2021-02-20 | James Madison (202) | 0 | 0 | Delaware (287) | Cancelled | - | - |
| 39 | 2021-02-21 | James Madison (202) | 0 | 0 | Delaware (287) | Cancelled | - | - |
| 40 | 2021-02-26 | Drexel (215) | 84 | 78 | James Madison (202) | Final | L | -6 |
| 41 | 2021-03-07 | Elon (232) | 72 | 71 | James Madison (202) | Final | L | -1 |