Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2017-11-12 | George Mason (107) | 61 | 72 | Louisville (12) | Final | W | 11 |
| 2 | 2017-11-17 | Nebraska-Omaha (165) | 78 | 87 | Louisville (12) | Final | W | 9 |
| 3 | 2017-11-21 | Southern Illinois (155) | 42 | 84 | Louisville (87) | Final | W | 42 |
| 4 | 2017-11-24 | St. Francis (PA) (229) | 72 | 84 | Louisville (87) | Final | W | 12 |
| 5 | 2017-11-28 | Louisville (54) | 57 | 66 | Purdue (34) | Final | L | -9 |
| 6 | 2017-12-03 | Seton Hall (39) | 79 | 77 | Louisville (54) | Final | L | -2 |
| 7 | 2017-12-06 | Siena (264) | 60 | 86 | Louisville (71) | Final | W | 26 |
| 8 | 2017-12-09 | Indiana (165) | 62 | 71 | Louisville (71) | Final | W | 9 |
| 9 | 2017-12-11 | Bryant (333) | 59 | 102 | Louisville (71) | Final | W | 43 |
| 10 | 2017-12-16 | Louisville (55) | 81 | 72 | Memphis (124) | Final | W | 9 |
| 11 | 2017-12-20 | Albany (115) | 68 | 70 | Louisville (40) | Final | W | 2 |
| 12 | 2017-12-23 | Grand Canyon (105) | 56 | 74 | Louisville (40) | Final | W | 18 |
| 13 | 2017-12-29 | Louisville (28) | 61 | 90 | Kentucky (36) | Final | L | -29 |
| 14 | 2018-01-02 | Pittsburgh (133) | 51 | 77 | Louisville (45) | Final | W | 26 |
| 15 | 2018-01-06 | Louisville (45) | 69 | 74 | Clemson (16) | Final/OT | L | -5 |
| 16 | 2018-01-10 | Louisville (37) | 73 | 69 | Florida State (23) | Final | W | 4 |
| 17 | 2018-01-13 | Virginia Tech (48) | 86 | 94 | Louisville (37) | Final | W | 8 |
| 18 | 2018-01-16 | Louisville (29) | 82 | 78 | Notre Dame (40) | Final/2OT | W | 4 |
| 19 | 2018-01-21 | Boston College (69) | 69 | 77 | Louisville (29) | Final | W | 8 |
| 20 | 2018-01-24 | Louisville (24) | 75 | 78 | Miami (34) | Final/OT | L | -3 |
| 21 | 2018-01-27 | Wake Forest (123) | 77 | 96 | Louisville (24) | Final | W | 19 |
| 22 | 2018-01-31 | Louisville (27) | 64 | 74 | Virginia (1) | Final | L | -10 |
| 23 | 2018-02-03 | Florida State (25) | 80 | 76 | Louisville (27) | Final | L | -4 |
| 24 | 2018-02-05 | Syracuse (53) | 78 | 73 | Louisville (31) | Final | L | -5 |
| 25 | 2018-02-08 | Georgia Tech (109) | 54 | 77 | Louisville (31) | Final | W | 23 |
| 26 | 2018-02-11 | Louisville (31) | 94 | 60 | Pittsburgh (182) | Final | W | 34 |
| 27 | 2018-02-17 | North Carolina (14) | 93 | 76 | Louisville (33) | Final | L | -17 |
| 28 | 2018-02-21 | Louisville (37) | 56 | 82 | Duke (5) | Final | L | -26 |
| 29 | 2018-02-24 | Louisville (37) | 75 | 68 | Virginia Tech (33) | Final | W | 7 |
| 30 | 2018-03-01 | Virginia (1) | 67 | 66 | Louisville (36) | Final | L | -1 |
| 31 | 2018-03-03 | Louisville (36) | 69 | 76 | North Carolina State (32) | Final | L | -7 |
| 32 | 2018-03-07 | Louisville (40) | 82 | 74 | Florida State (35) | Final | W | 8 |
| 33 | 2018-03-08 | Louisville (40) | 58 | 75 | Virginia (1) | Final | L | -17 |
| 34 | 2018-03-13 | Northern Kentucky (195) | 58 | 66 | Louisville (21) | Final | W | 8 |
| 35 | 2018-03-18 | Middle Tennessee (56) | 68 | 84 | Louisville (35) | Final | W | 16 |
| 36 | 2018-03-20 | Mississippi State (54) | 79 | 56 | Louisville (35) | Final | L | -23 |