Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2017-11-10 | SIU-Edwardsville (328) | 74 | 105 | Purdue (15) | Final | W | 31 |
| 2 | 2017-11-12 | Chicago State (335) | 42 | 111 | Purdue (15) | Final | W | 69 |
| 3 | 2017-11-14 | Purdue (15) | 86 | 71 | Marquette (42) | Final | W | 15 |
| 4 | 2017-11-18 | Fairfield (204) | 64 | 106 | Purdue (15) | Final | W | 42 |
| 5 | 2017-11-22 | Tennessee (58) | 78 | 75 | Purdue (2) | Final/OT | L | -3 |
| 6 | 2017-11-23 | Purdue (2) | 73 | 77 | Western Kentucky (177) | Final | L | -4 |
| 7 | 2017-11-24 | Arizona (24) | 64 | 89 | Purdue (2) | Final | W | 25 |
| 8 | 2017-11-28 | Louisville (54) | 57 | 66 | Purdue (34) | Final | W | 9 |
| 9 | 2017-12-01 | Purdue (34) | 80 | 75 | Maryland (42) | Final | W | 5 |
| 10 | 2017-12-03 | Northwestern (100) | 69 | 74 | Purdue (34) | Final | W | 5 |
| 11 | 2017-12-07 | Valparaiso (44) | 50 | 80 | Purdue (17) | Final | W | 30 |
| 12 | 2017-12-10 | IUPUI (296) | 61 | 86 | Purdue (17) | Final | W | 25 |
| 13 | 2017-12-16 | Purdue (12) | 82 | 67 | Butler (37) | Final | W | 15 |
| 14 | 2017-12-21 | Tennessee State (234) | 48 | 97 | Purdue (10) | Final | W | 49 |
| 15 | 2017-12-30 | Lipscomb (105) | 66 | 98 | Purdue (7) | Final | W | 32 |
| 16 | 2018-01-03 | Rutgers (100) | 51 | 82 | Purdue (6) | Final | W | 31 |
| 17 | 2018-01-06 | Nebraska (77) | 62 | 74 | Purdue (6) | Final | W | 12 |
| 18 | 2018-01-09 | Purdue (5) | 70 | 69 | Michigan (32) | Final | W | 1 |
| 19 | 2018-01-13 | Purdue (5) | 81 | 47 | Minnesota (51) | Final | W | 34 |
| 20 | 2018-01-16 | Wisconsin (100) | 50 | 78 | Purdue (3) | Final | W | 28 |
| 21 | 2018-01-20 | Purdue (3) | 87 | 64 | Iowa (108) | Final | W | 23 |
| 22 | 2018-01-25 | Michigan (29) | 88 | 92 | Purdue (3) | Final | W | 4 |
| 23 | 2018-01-28 | Purdue (3) | 74 | 67 | Indiana (91) | Final | W | 7 |
| 24 | 2018-01-31 | Maryland (52) | 67 | 75 | Purdue (3) | Final | W | 8 |
| 25 | 2018-02-03 | Purdue (3) | 78 | 76 | Rutgers (118) | Final | W | 2 |
| 26 | 2018-02-07 | Ohio State (14) | 64 | 63 | Purdue (3) | Final | L | -1 |
| 27 | 2018-02-10 | Purdue (3) | 65 | 68 | Michigan State (6) | Final | L | -3 |
| 28 | 2018-02-15 | Purdue (5) | 53 | 57 | Wisconsin (107) | Final | L | -4 |
| 29 | 2018-02-18 | Penn State (56) | 73 | 76 | Purdue (5) | Final | W | 3 |
| 30 | 2018-02-22 | Purdue (6) | 93 | 86 | Illinois (112) | Final | W | 7 |
| 31 | 2018-02-25 | Minnesota (93) | 60 | 84 | Purdue (6) | Final | W | 24 |
| 32 | 2018-03-02 | Rutgers (145) | 75 | 82 | Purdue (6) | Final | W | 7 |
| 33 | 2018-03-03 | Penn State (58) | 70 | 78 | Purdue (6) | Final | W | 8 |
| 34 | 2018-03-04 | Michigan (19) | 75 | 66 | Purdue (6) | Final | L | -9 |
| 35 | 2018-03-16 | Cal State-Fullerton (154) | 48 | 74 | Purdue (11) | Final - 0:00 | W | 26 |
| 36 | 2018-03-18 | Butler (107) | 73 | 76 | Purdue (11) | Final - 0:00 | W | 3 |
| 37 | 2018-03-23 | Texas Tech (12) | 78 | 65 | Purdue (11) | Final - 0:00 | L | -13 |