Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2017-11-10 | Western Carolina (308) | 57 | 85 | Clemson (52) | Final | W | 28 |
| 2 | 2017-11-12 | North Carolina A&T (350) | 63 | 87 | Clemson (52) | Final | W | 24 |
| 3 | 2017-11-16 | Clemson (52) | 81 | 76 | Ohio (118) | Final | W | 5 |
| 4 | 2017-11-17 | Clemson (52) | 78 | 59 | Hofstra (203) | Final | W | 19 |
| 5 | 2017-11-19 | Temple (113) | 67 | 60 | Clemson (52) | Final | L | -7 |
| 6 | 2017-11-24 | Texas Southern (290) | 77 | 84 | Clemson (25) | Final | W | 7 |
| 7 | 2017-11-29 | Clemson (55) | 79 | 65 | Ohio State (80) | Final | W | 14 |
| 8 | 2017-12-03 | UNC-Asheville (145) | 52 | 83 | Clemson (55) | Final | W | 31 |
| 9 | 2017-12-09 | Samford (309) | 59 | 81 | Clemson (35) | Final | W | 22 |
| 10 | 2017-12-16 | Clemson (29) | 71 | 69 | Florida (41) | Final | W | 2 |
| 11 | 2017-12-19 | South Carolina (60) | 48 | 64 | Clemson (22) | Final | W | 16 |
| 12 | 2017-12-22 | Louisiana (93) | 60 | 89 | Clemson (22) | Final | W | 29 |
| 13 | 2017-12-30 | North Carolina State (57) | 62 | 78 | Clemson (18) | Final | W | 16 |
| 14 | 2018-01-03 | Clemson (16) | 74 | 70 | Boston College (66) | Final | W | 4 |
| 15 | 2018-01-06 | Louisville (45) | 69 | 74 | Clemson (16) | Final/OT | W | 5 |
| 16 | 2018-01-11 | Clemson (8) | 77 | 78 | North Carolina State (58) | Final | L | -1 |
| 17 | 2018-01-13 | Miami (30) | 63 | 72 | Clemson (8) | Final | W | 9 |
| 18 | 2018-01-16 | Clemson (12) | 79 | 87 | North Carolina (14) | Final | L | -8 |
| 19 | 2018-01-20 | Notre Dame (40) | 58 | 67 | Clemson (12) | Final | W | 9 |
| 20 | 2018-01-23 | Clemson (11) | 36 | 61 | Virginia (2) | Final | L | -25 |
| 21 | 2018-01-28 | Clemson (11) | 72 | 70 | Georgia Tech (113) | Final | W | 2 |
| 22 | 2018-01-30 | North Carolina (14) | 78 | 82 | Clemson (11) | Final | W | 4 |
| 23 | 2018-02-03 | Clemson (11) | 75 | 67 | Wake Forest (124) | Final | W | 8 |
| 24 | 2018-02-08 | Pittsburgh (182) | 48 | 72 | Clemson (12) | Final | W | 24 |
| 25 | 2018-02-14 | Clemson (11) | 79 | 81 | Florida State (36) | Final/OT | L | -2 |
| 26 | 2018-02-18 | Duke (9) | 66 | 57 | Clemson (11) | Final | L | -9 |
| 27 | 2018-02-21 | Clemson (15) | 58 | 65 | Virginia Tech (33) | Final | L | -7 |
| 28 | 2018-02-24 | Georgia Tech (128) | 67 | 75 | Clemson (15) | Final | W | 8 |
| 29 | 2018-02-28 | Florida State (37) | 63 | 76 | Clemson (17) | Final | W | 13 |
| 30 | 2018-03-03 | Clemson (17) | 52 | 55 | Syracuse (49) | Final | L | -3 |
| 31 | 2018-03-08 | Boston College (74) | 82 | 90 | Clemson (18) | Final | W | 8 |
| 32 | 2018-03-09 | Clemson (18) | 58 | 64 | Virginia (1) | Final | L | -6 |
| 33 | 2018-03-16 | New Mexico State (68) | 68 | 79 | Clemson (89) | Final - 0:00 | W | 11 |
| 34 | 2018-03-18 | Clemson (89) | 84 | 53 | Auburn (6) | Final - 0:00 | W | 31 |
| 35 | 2018-03-23 | Clemson (89) | 76 | 80 | Kansas (3) | Final - 0:00 | L | -4 |