Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-30 | Little Rock (321) | 76 | 66 | Duquesne (121) | Final | L | -10 |
| 2 | 2020-12-02 | UNC-Greensboro (265) | 68 | 81 | Duquesne (121) | Final | W | 13 |
| 3 | 2020-12-04 | Duquesne (121) | 0 | 0 | Winthrop (133) | Cancelled | - | - |
| 4 | 2020-12-04 | Duquesne (162) | Winthrop (229) | Cancelled | - | - | ||
| 5 | 2020-12-19 | Duquesne (121) | 0 | 0 | Richmond (166) | Postponed | - | - |
| 6 | 2020-12-30 | Duquesne (121) | 0 | 0 | Saint Louis (31) | Cancelled | - | - |
| 7 | 2021-01-02 | Duquesne (121) | 75 | 63 | George Washington (104) | Final | W | 12 |
| 8 | 2021-01-03 | Duquesne (121) | 73 | 75 | George Washington (104) | Final | L | -2 |
| 9 | 2021-01-05 | Davidson (111) | 61 | 48 | Duquesne (121) | Final | L | -13 |
| 10 | 2021-01-09 | Fordham (183) | 45 | 48 | Duquesne (121) | Final | W | 3 |
| 11 | 2021-01-13 | Duquesne (121) | 63 | 72 | Dayton (66) | Final | L | -9 |
| 12 | 2021-01-15 | Duquesne (121) | 48 | 62 | St. Bonaventure (146) | Final | L | -14 |
| 13 | 2021-01-20 | Rhode Island (145) | 69 | 71 | Duquesne (121) | Final | W | 2 |
| 14 | 2021-01-23 | St. Bonaventure (146) | 65 | 61 | Duquesne (121) | Final | L | -4 |
| 15 | 2021-01-27 | Duquesne (121) | 86 | 62 | Fordham (183) | Final | W | 24 |
| 16 | 2021-01-30 | Saint Joseph's (99) | 50 | 67 | Duquesne (121) | Final | W | 17 |
| 17 | 2021-02-02 | Dayton (66) | 64 | 69 | Duquesne (121) | Final | W | 5 |
| 18 | 2021-02-07 | Virginia Commonwealth (45) | 0 | 0 | Duquesne (138) | Cancelled | - | - |
| 19 | 2021-02-13 | Duquesne (121) | 0 | 0 | George Mason (86) | Cancelled | - | - |
| 20 | 2021-02-17 | Duquesne (121) | 0 | 0 | George Mason (86) | Cancelled | - | - |
| 21 | 2021-02-17 | Duquesne (145) | 0 | 0 | Davidson (82) | Cancelled | - | - |
| 22 | 2021-02-20 | Duquesne (121) | 72 | 79 | Richmond (166) | Final | L | -7 |
| 23 | 2021-02-24 | George Washington | Duquesne | Cancelled | - | - | ||
| 24 | 2021-02-24 | Duquesne (121) | 65 | 85 | La Salle (237) | Final | L | -20 |
| 25 | 2021-02-27 | Rhode Island (145) | 75 | 86 | Duquesne (121) | Final | W | 11 |
| 26 | 2021-03-04 | Duquesne (121) | 67 | 62 | Richmond (166) | Final | W | 5 |
| 27 | 2021-03-05 | Duquesne (121) | 59 | 75 | St. Bonaventure (146) | Final | L | -16 |