Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-11-08 | Milwaukee (184) | 53 | 84 | Purdue (4) | Final | W | 31 |
| 2 | 2022-11-11 | Austin Peay (320) | 44 | 63 | Purdue (4) | Final | W | 19 |
| 3 | 2022-11-15 | Marquette (14) | 70 | 75 | Purdue (4) | Final | W | 5 |
| 4 | 2022-11-24 | Purdue (4) | 80 | 68 | West Virginia (42) | Final | W | 12 |
| 5 | 2022-11-25 | Purdue (4) | 84 | 66 | Gonzaga (8) | Final | W | 18 |
| 6 | 2022-11-27 | Duke (25) | 56 | 75 | Purdue (4) | Final | W | 19 |
| 7 | 2022-11-30 | Purdue (8) | 79 | 69 | Florida State (64) | Final | W | 10 |
| 8 | 2022-12-04 | Minnesota (214) | 70 | 89 | Purdue (4) | Final | W | 19 |
| 9 | 2022-12-07 | Hofstra (88) | 66 | 85 | Purdue (4) | Final | W | 19 |
| 10 | 2022-12-10 | Purdue (4) | 65 | 62 | Nebraska (83) | Final | W | 3 |
| 11 | 2022-12-17 | Davidson (153) | 61 | 69 | Purdue (4) | Final | W | 8 |
| 12 | 2022-12-21 | New Orleans (236) | 53 | 74 | Purdue (8) | Final | W | 21 |
| 13 | 2022-12-29 | Florida A&M (297) | 49 | 82 | Purdue (8) | Final | W | 33 |
| 14 | 2023-01-02 | Rutgers (40) | 65 | 64 | Purdue (4) | Final | L | -1 |
| 15 | 2023-01-05 | Purdue (4) | 71 | 69 | Ohio State (92) | Final | W | 2 |
| 16 | 2023-01-08 | Purdue (4) | 76 | 63 | Penn State (54) | Final | W | 13 |
| 17 | 2023-01-13 | Nebraska (83) | 55 | 73 | Purdue (4) | Final | W | 18 |
| 18 | 2023-01-16 | Purdue (4) | 64 | 63 | Michigan State (41) | Final | W | 1 |
| 19 | 2023-01-19 | Purdue (4) | 61 | 39 | Minnesota (214) | Final | W | 22 |
| 20 | 2023-01-22 | Maryland (28) | 55 | 58 | Purdue (4) | Final | W | 3 |
| 21 | 2023-01-26 | Purdue (4) | 75 | 70 | Michigan (55) | Final | W | 5 |
| 22 | 2023-01-29 | Michigan State (41) | 61 | 77 | Purdue (4) | Final | W | 16 |
| 23 | 2023-02-01 | Penn State (54) | 60 | 80 | Purdue (4) | Final | W | 20 |
| 24 | 2023-02-04 | Purdue (4) | 74 | 79 | Indiana (19) | Final | L | -5 |
| 25 | 2023-02-09 | Iowa (43) | 73 | 87 | Purdue (4) | Final | W | 14 |
| 26 | 2023-02-12 | Purdue (4) | 58 | 64 | Northwestern (24) | Final | L | -6 |
| 27 | 2023-02-16 | Purdue (4) | 54 | 68 | Maryland (28) | Final | L | -14 |
| 28 | 2023-02-19 | Ohio State (92) | 55 | 82 | Purdue (4) | Final | W | 27 |
| 29 | 2023-02-25 | Indiana (17) | 79 | 71 | Purdue (5) | Final | L | -8 |
| 30 | 2023-03-02 | Purdue (8) | 63 | 61 | Wisconsin (24) | Final | W | 2 |
| 31 | 2023-03-05 | Illinois (35) | 71 | 76 | Purdue (5) | Final | W | 5 |
| 32 | 2023-03-10 | Rutgers (48) | 65 | 70 | Purdue (6) | Final | W | 5 |
| 33 | 2023-03-11 | Ohio State (71) | 66 | 80 | Purdue (5) | Final | W | 14 |
| 34 | 2023-03-12 | Penn State (41) | 65 | 67 | Purdue (3) | Final | W | 2 |
| 35 | 2023-03-17 | Fairleigh Dickinson | 63 | 58 | Purdue | Final | L | -5 |