Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-11-07 | Northern Arizona (294) | 55 | 73 | Michigan State (41) | Final | W | 18 |
| 2 | 2022-11-11 | Michigan State (41) | 63 | 64 | Gonzaga (8) | Final | L | -1 |
| 3 | 2022-11-15 | Kentucky (33) | 77 | 86 | Michigan State (41) | Final | W | 9 |
| 4 | 2022-11-18 | Villanova (93) | 71 | 73 | Michigan State (41) | Final | W | 2 |
| 5 | 2022-11-24 | Alabama (2) | 81 | 70 | Michigan State (41) | Final | L | -11 |
| 6 | 2022-11-26 | Oregon (60) | 70 | 74 | Michigan State (41) | Final | W | 4 |
| 7 | 2022-11-27 | Michigan State (41) | 78 | 77 | Portland (177) | Final | W | 1 |
| 8 | 2022-11-30 | Michigan State (41) | 52 | 70 | Notre Dame (199) | Final | L | -18 |
| 9 | 2022-12-04 | Northwestern (24) | 70 | 63 | Michigan State (41) | Final | L | -7 |
| 10 | 2022-12-07 | Michigan State (41) | 67 | 58 | Penn State (54) | Final | W | 9 |
| 11 | 2022-12-10 | Brown (187) | 50 | 68 | Michigan State (41) | Final | W | 18 |
| 12 | 2022-12-21 | Oakland (262) | 54 | 67 | Michigan State (41) | Final | W | 13 |
| 13 | 2022-12-30 | Buffalo (202) | 68 | 89 | Michigan State (41) | Final | W | 21 |
| 14 | 2023-01-03 | Nebraska (83) | 56 | 74 | Michigan State (41) | Final | W | 18 |
| 15 | 2023-01-07 | Michigan (55) | 53 | 59 | Michigan State (41) | Final | W | 6 |
| 16 | 2023-01-10 | Michigan State (41) | 69 | 65 | Wisconsin (53) | Final | W | 4 |
| 17 | 2023-01-13 | Michigan State (41) | 66 | 75 | Illinois (34) | Final | L | -9 |
| 18 | 2023-01-16 | Purdue (4) | 64 | 63 | Michigan State (41) | Final | L | -1 |
| 19 | 2023-01-19 | Rutgers (40) | 57 | 70 | Michigan State (41) | Final | W | 13 |
| 20 | 2023-01-22 | Michigan State (41) | 69 | 82 | Indiana (19) | Final | L | -13 |
| 21 | 2023-01-26 | Iowa (43) | 61 | 63 | Michigan State (41) | Final | W | 2 |
| 22 | 2023-01-29 | Michigan State (41) | 61 | 77 | Purdue (4) | Final | L | -16 |
| 23 | 2023-02-04 | Michigan State (41) | 55 | 61 | Rutgers (40) | Final | L | -6 |
| 24 | 2023-02-07 | Maryland (28) | 58 | 63 | Michigan State (41) | Final | W | 5 |
| 25 | 2023-02-12 | Michigan State (41) | 62 | 41 | Ohio State (92) | Final | W | 21 |
| 26 | 2023-02-15 | Minnesota (214) | 0 | 0 | Michigan State (41) | Scheduled - 08:00PM ET | - | - |
| 27 | 2023-02-18 | Michigan State (41) | 72 | 84 | Michigan (55) | Final | L | -12 |
| 28 | 2023-02-21 | Indiana (19) | 65 | 80 | Michigan State (41) | Final | W | 15 |
| 29 | 2023-02-25 | Michigan State (41) | 106 | 112 | Iowa (45) | Final | L | -6 |
| 30 | 2023-02-28 | Michigan State (34) | 80 | 67 | Nebraska (83) | Final | W | 13 |
| 31 | 2023-03-04 | Ohio State (86) | 78 | 84 | Michigan State (36) | Final | W | 6 |
| 32 | 2023-03-10 | Ohio State (72) | 68 | 58 | Michigan State (34) | Final | L | -10 |
| 33 | 2023-03-17 | USC | 62 | 72 | Michigan State | Final | W | 10 |
| 34 | 2023-03-19 | Michigan State (38) | 69 | 60 | Marquette (9) | Final | W | 9 |
| 35 | 2023-03-23 | Michigan State (38) | 93 | 98 | Kansas State (16) | Final (OT) | L | -5 |