Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2024-11-04 | Morehead State (233) | 45 | 93 | Louisville (21) | Final | W | 48 |
| 2 | 2024-11-09 | Tennessee (18) | 77 | 55 | Louisville (21) | Final | L | -22 |
| 3 | 2024-11-19 | Bellarmine (357) | 68 | 100 | Louisville (113) | Final | W | 32 |
| 4 | 2024-11-22 | Winthrop (184) | 61 | 76 | Louisville (66) | Final | W | 15 |
| 5 | 2024-11-27 | Indiana (73) | 61 | 89 | Louisville (24) | Final | W | 28 |
| 6 | 2024-11-28 | West Virginia (46) | 70 | 79 | Louisville (17) | Final (OT) | W | 9 |
| 7 | 2024-11-29 | Oklahoma (15) | 69 | 64 | Louisville (23) | Final | L | -5 |
| 8 | 2024-12-03 | Ole Miss (26) | 86 | 63 | Louisville (44) | Final | L | -23 |
| 9 | 2024-12-08 | Duke (12) | 76 | 65 | Louisville (55) | Final | L | -11 |
| 10 | 2024-12-11 | UTEP (161) | 74 | 77 | Louisville (49) | Final | W | 3 |
| 11 | 2024-12-14 | Louisville (60) | 85 | 93 | Kentucky (5) | Final | L | -8 |
| 12 | 2024-12-21 | Louisville (50) | 90 | 76 | Florida State (75) | Final | W | 14 |
| 13 | 2024-12-28 | Eastern Kentucky (239) | 76 | 78 | Louisville (54) | Final | W | 2 |
| 14 | 2025-01-01 | North Carolina (53) | 70 | 83 | Louisville (38) | Final | W | 13 |
| 15 | 2025-01-04 | Louisville (31) | 70 | 50 | Virginia (86) | Final | W | 20 |
| 16 | 2025-01-07 | Clemson (37) | 64 | 74 | Louisville (26) | Final | W | 10 |
| 17 | 2025-01-11 | Louisville (24) | 82 | 78 | Pittsburgh (26) | Final | W | 4 |
| 18 | 2025-01-14 | Louisville (25) | 85 | 61 | Syracuse (121) | Final | W | 24 |
| 19 | 2025-01-18 | Virginia (116) | 67 | 81 | Louisville (20) | Final | W | 14 |
| 20 | 2025-01-21 | Louisville (18) | 98 | 73 | SMU (45) | Final | W | 25 |
| 21 | 2025-01-28 | Wake Forest (49) | 59 | 72 | Louisville (16) | Final | W | 13 |
| 22 | 2025-02-01 | Louisville (26) | 70 | 77 | Georgia Tech (129) | Final | L | -7 |
| 23 | 2025-02-05 | Louisville (23) | 84 | 58 | Boston College (170) | Final | W | 26 |
| 24 | 2025-02-08 | Miami (234) | 78 | 88 | Louisville (23) | Final | W | 10 |
| 25 | 2025-02-12 | Louisville (21) | 91 | 66 | North Carolina State (142) | Final | W | 25 |
| 26 | 2025-02-16 | Louisville (20) | 75 | 60 | Notre Dame (122) | Final | W | 15 |
| 27 | 2025-02-22 | Florida State (85) | 81 | 89 | Louisville (20) | Final | W | 8 |
| 28 | 2025-02-25 | Louisville (21) | 71 | 66 | Virginia Tech (56) | Final | W | 5 |
| 29 | 2025-03-01 | Pittsburgh (108) | 68 | 79 | Louisville (21) | Final | W | 11 |
| 30 | 2025-03-05 | California (119) | 68 | 85 | Louisville (18) | Final | W | 17 |
| 31 | 2025-03-08 | Stanford (75) | 48 | 68 | Louisville (13) | Final | W | 20 |
| 32 | 2025-03-13 | Stanford (72) | 73 | 75 | Louisville (13) | Final | W | 2 |
| 33 | 2025-03-14 | Clemson (11) | 73 | 76 | Louisville (13) | Final | W | 3 |
| 34 | 2025-03-15 | Louisville | 62 | 73 | Duke | Final | L | -11 |
| 35 | 2025-03-20 | Creighton (36) | 89 | 75 | Louisville (10) | Final | L | -14 |