Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2024-11-04 | Maine (158) | 62 | 96 | Duke (75) | Final | W | 34 |
| 2 | 2024-11-08 | Army (194) | 58 | 100 | Duke (1) | Final | W | 42 |
| 3 | 2024-11-12 | Duke (26) | 72 | 77 | Kentucky (1) | Final | L | -5 |
| 4 | 2024-11-16 | Wofford (343) | 35 | 86 | Duke (38) | Final | W | 51 |
| 5 | 2024-11-22 | Duke (22) | 69 | 55 | Arizona (128) | Final | W | 14 |
| 6 | 2024-11-26 | Kansas (7) | 75 | 72 | Duke (43) | Final | L | -3 |
| 7 | 2024-11-29 | Seattle (239) | 48 | 70 | Duke (33) | Final | W | 22 |
| 8 | 2024-12-04 | Auburn (4) | 78 | 84 | Duke (20) | Final | W | 6 |
| 9 | 2024-12-08 | Duke (12) | 76 | 65 | Louisville (55) | Final | W | 11 |
| 10 | 2024-12-10 | Incarnate Word (250) | 46 | 72 | Duke (11) | Final | W | 26 |
| 11 | 2024-12-17 | George Mason (115) | 47 | 68 | Duke (7) | Final | W | 21 |
| 12 | 2024-12-21 | Duke (7) | 82 | 56 | Georgia Tech (161) | Final | W | 26 |
| 13 | 2024-12-31 | Virginia Tech (163) | 65 | 88 | Duke (7) | Final | W | 23 |
| 14 | 2025-01-04 | Duke (4) | 89 | 62 | SMU (36) | Final | W | 27 |
| 15 | 2025-01-07 | Pittsburgh (22) | 47 | 76 | Duke (3) | Final | W | 29 |
| 16 | 2025-01-11 | Notre Dame (112) | 78 | 86 | Duke (3) | Final | W | 8 |
| 17 | 2025-01-14 | Miami (227) | 54 | 89 | Duke (2) | Final | W | 35 |
| 18 | 2025-01-18 | Duke (2) | 88 | 63 | Boston College (176) | Final | W | 25 |
| 19 | 2025-01-25 | Duke (2) | 63 | 56 | Wake Forest (49) | Final | W | 7 |
| 20 | 2025-01-27 | North Carolina State (114) | 64 | 74 | Duke (2) | Final | W | 10 |
| 21 | 2025-02-01 | North Carolina (47) | 70 | 87 | Duke (2) | Final | W | 17 |
| 22 | 2025-02-05 | Duke (2) | 83 | 54 | Syracuse (117) | Final | W | 29 |
| 23 | 2025-02-08 | Duke (5) | 71 | 77 | Clemson (28) | Final | L | -6 |
| 24 | 2025-02-12 | California (110) | 57 | 78 | Duke (4) | Final | W | 21 |
| 25 | 2025-02-15 | Stanford (75) | 70 | 106 | Duke (3) | Final | W | 36 |
| 26 | 2025-02-17 | Duke (3) | 80 | 62 | Virginia (97) | Final | W | 18 |
| 27 | 2025-02-22 | Illinois (31) | 67 | 110 | Duke (3) | Final | W | 43 |
| 28 | 2025-02-25 | Duke (2) | 97 | 60 | Miami (230) | Final | W | 37 |
| 29 | 2025-03-01 | Florida State (87) | 65 | 100 | Duke (2) | Final | W | 35 |
| 30 | 2025-03-03 | Wake Forest (56) | 60 | 93 | Duke (2) | Final | W | 33 |
| 31 | 2025-03-08 | Duke (2) | 82 | 69 | North Carolina (41) | Final | W | 13 |
| 32 | 2025-03-13 | Georgia Tech (100) | 70 | 78 | Duke (2) | Final | W | 8 |
| 33 | 2025-03-14 | North Carolina (41) | 71 | 74 | Duke (2) | Final | W | 3 |
| 34 | 2025-03-15 | Louisville | 62 | 73 | Duke | Final | W | 11 |
| 35 | 2025-03-21 | Mount St Mary’s (189) | 49 | 93 | Duke (3) | Final | W | 44 |
| 36 | 2025-03-23 | Baylor (43) | 66 | 89 | Duke (3) | Final | W | 23 |
| 37 | 2025-03-27 | Arizona (21) | 93 | 100 | Duke (3) | Final | W | 7 |
| 38 | 2025-03-29 | Alabama (6) | 65 | 85 | Duke (3) | Final | W | 20 |
| 39 | 2025-04-05 | Houston (4) | 70 | 67 | Duke (3) | Final | L | -3 |