Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-11-07 | La Salle (182) | 68 | 81 | Villanova (93) | Final | L | -13 |
| 2 | 2022-11-12 | Wagner (301) | 69 | 77 | La Salle (182) | Final | W | 8 |
| 3 | 2022-11-15 | Queens (206) | 60 | 72 | La Salle (182) | Final | W | 12 |
| 4 | 2022-11-18 | La Salle (182) | 63 | 75 | Wake Forest (59) | Final | L | -12 |
| 5 | 2022-11-20 | La Salle (182) | 62 | 69 | Georgetown (215) | Final | L | -7 |
| 6 | 2022-11-26 | Binghamton (272) | 62 | 65 | La Salle (182) | Final | W | 3 |
| 7 | 2022-11-30 | Temple (169) | 67 | 51 | La Salle (237) | Final | L | -16 |
| 8 | 2022-12-03 | La Salle (237) | 84 | 81 | Penn (131) | Final/OT | W | 3 |
| 9 | 2022-12-06 | Bucknell (336) | 72 | 82 | La Salle (237) | Final | W | 10 |
| 10 | 2022-12-10 | Drexel (217) | 65 | 58 | La Salle (182) | Final | L | -7 |
| 11 | 2022-12-17 | La Salle (182) | 60 | 78 | Cincinnati (74) | Final | L | -18 |
| 12 | 2022-12-21 | Lafayette (323) | 90 | 65 | La Salle (237) | Final | L | -25 |
| 13 | 2022-12-29 | La Salle (237) | 80 | 76 | Howard (211) | Final | W | 4 |
| 14 | 2022-12-31 | La Salle (182) | 67 | 80 | Virginia Commonwealth (57) | Final | L | -13 |
| 15 | 2023-01-07 | Rhode Island (234) | 75 | 77 | La Salle (182) | Final | W | 2 |
| 16 | 2023-01-11 | La Salle (182) | 78 | 77 | Massachusetts (155) | Final | W | 1 |
| 17 | 2023-01-14 | Fordham (86) | 66 | 64 | La Salle (182) | Final | L | -2 |
| 18 | 2023-01-16 | Saint Joseph's (170) | 71 | 59 | La Salle (182) | Final | L | -12 |
| 19 | 2023-01-21 | La Salle (182) | 71 | 84 | Saint Louis (80) | Final | L | -13 |
| 20 | 2023-01-24 | Davidson (153) | 64 | 57 | La Salle (182) | Final | L | -7 |
| 21 | 2023-01-28 | La Salle (182) | 70 | 72 | Rhode Island (234) | Final | L | -2 |
| 22 | 2023-02-01 | George Washington (191) | 64 | 75 | La Salle (182) | Final | W | 11 |
| 23 | 2023-02-05 | La Salle (182) | 73 | 65 | Saint Joseph's (170) | Final | W | 8 |
| 24 | 2023-02-08 | La Salle (182) | 76 | 70 | St. Bonaventure (171) | Final | W | 6 |
| 25 | 2023-02-11 | Massachusetts (182) | 72 | 86 | La Salle (237) | Final | W | 14 |
| 26 | 2023-02-15 | Richmond (166) | 62 | 68 | La Salle (237) | Final | W | 6 |
| 27 | 2023-02-18 | La Salle (237) | 66 | 70 | George Mason (86) | Final | L | -4 |
| 28 | 2023-02-22 | Duquesne (121) | 91 | 74 | La Salle (237) | Final | L | -17 |
| 29 | 2023-02-25 | La Salle (198) | 85 | 92 | George Washington (174) | Final | L | -7 |
| 30 | 2023-02-28 | La Salle (206) | 53 | 77 | Dayton (76) | Final | L | -24 |
| 31 | 2023-03-04 | Loyola-Chicago (263) | 76 | 73 | La Salle (237) | Final | L | -3 |
| 32 | 2023-03-07 | Rhode Island (244) | 56 | 73 | La Salle (204) | Final | W | 17 |
| 33 | 2023-03-08 | La Salle (195) | 81 | 70 | Duquesne (108) | Final | W | 11 |
| 34 | 2023-03-09 | La Salle (195) | 61 | 69 | Fordham (88) | Final | L | -8 |