Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-11-07 | Fairleigh-Dickinson (286) | 82 | 88 | Loyola-Chicago (245) | Final | W | 6 |
| 2 | 2022-11-11 | Loyola-Chicago (245) | 70 | 63 | Illinois-Chicago (271) | Final | W | 7 |
| 3 | 2022-11-17 | Loyola-Chicago (245) | 66 | 85 | Tulsa (306) | Final | L | -19 |
| 4 | 2022-11-18 | Boise State (30) | 70 | 48 | Loyola-Chicago (245) | Final | L | -22 |
| 5 | 2022-11-20 | Texas A&M (29) | 67 | 51 | Loyola-Chicago (245) | Final | L | -16 |
| 6 | 2022-11-25 | Loyola-Chicago (245) | 55 | 61 | Harvard (183) | Final | L | -6 |
| 7 | 2022-11-30 | Central Arkansas (310) | 70 | 85 | Loyola-Chicago (245) | Final | W | 15 |
| 8 | 2022-12-03 | DePaul (159) | 78 | 72 | Loyola-Chicago (245) | Final | L | -6 |
| 9 | 2022-12-06 | Green Bay (360) | 46 | 70 | Loyola-Chicago (245) | Final | W | 24 |
| 10 | 2022-12-10 | Loyola-Chicago (245) | 76 | 58 | Clemson (63) | Final | W | 18 |
| 11 | 2022-12-18 | Albany (349) | 56 | 68 | Loyola-Chicago (245) | Final | W | 12 |
| 12 | 2022-12-22 | Loyola-Chicago (245) | 62 | 75 | Stanford (133) | Final | L | -13 |
| 13 | 2022-12-31 | George Washington (191) | 97 | 87 | Loyola-Chicago (245) | Final | L | -10 |
| 14 | 2023-01-04 | Loyola-Chicago (245) | 57 | 80 | Davidson (153) | Final | L | -23 |
| 15 | 2023-01-07 | Loyola-Chicago (245) | 75 | 86 | George Mason (131) | Final | L | -11 |
| 16 | 2023-01-10 | Virginia Commonwealth (57) | 78 | 64 | Loyola-Chicago (245) | Final | L | -14 |
| 17 | 2023-01-14 | Loyola-Chicago (245) | 55 | 86 | Saint Joseph's (170) | Final | L | -31 |
| 18 | 2023-01-18 | Saint Louis (80) | 76 | 59 | Loyola-Chicago (245) | Final | L | -17 |
| 19 | 2023-01-21 | St. Bonaventure (171) | 55 | 67 | Loyola-Chicago (245) | Final | W | 12 |
| 20 | 2023-01-25 | Loyola-Chicago (245) | 58 | 72 | Duquesne (94) | Final | L | -14 |
| 21 | 2023-01-31 | Loyola-Chicago (245) | 81 | 85 | Dayton (81) | Final | L | -4 |
| 22 | 2023-02-04 | George Mason (131) | 61 | 69 | Loyola-Chicago (245) | Final | W | 8 |
| 23 | 2023-02-08 | Saint Joseph's (170) | 83 | 71 | Loyola-Chicago (245) | Final | L | -12 |
| 24 | 2023-02-11 | Loyola-Chicago (245) | 71 | 74 | Richmond (157) | Final | L | -3 |
| 25 | 2023-02-14 | Loyola-Chicago (245) | 64 | 62 | Massachusetts (155) | Final | W | 2 |
| 26 | 2023-02-17 | Dayton (81) | 65 | 49 | Loyola-Chicago (245) | Final | L | -16 |
| 27 | 2023-02-22 | Fordham (85) | 71 | 69 | Loyola-Chicago (246) | Final | L | -2 |
| 28 | 2023-02-25 | Loyola-Chicago (247) | 62 | 81 | Saint Louis (85) | Final | L | -19 |
| 29 | 2023-03-01 | Rhode Island (237) | 79 | 77 | Loyola-Chicago (253) | Final | L | -2 |
| 30 | 2023-03-04 | Loyola-Chicago (247) | 76 | 73 | La Salle (214) | Final | W | 3 |
| 31 | 2023-03-07 | Loyola-Chicago (247) | 67 | 72 | Saint Joseph's (170) | Final | L | -5 |