Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-11-07 | Lafayette (298) | 54 | 67 | Miami (16) | Final | L | -13 |
| 2 | 2022-11-12 | Lafayette (298) | 68 | 83 | St. John's (85) | Final | L | -15 |
| 3 | 2022-11-14 | Lafayette (298) | 59 | 63 | Saint Joseph's (170) | Final | L | -4 |
| 4 | 2022-11-18 | Lafayette (298) | 63 | 71 | UMBC (223) | Final | L | -8 |
| 5 | 2022-11-19 | Central Connecticut State (330) | 50 | 55 | Lafayette (298) | Final | W | 5 |
| 6 | 2022-11-22 | Penn (146) | 74 | 68 | Lafayette (298) | Final | L | -6 |
| 7 | 2022-11-25 | Lafayette (298) | 57 | 70 | Penn State (54) | Final | L | -13 |
| 8 | 2022-11-30 | Lafayette (298) | 56 | 64 | Drexel (217) | Final | L | -8 |
| 9 | 2022-12-04 | Lafayette (298) | 68 | 73 | Cornell (140) | Final | L | -5 |
| 10 | 2022-12-06 | Lafayette (298) | 58 | 69 | Princeton (137) | Final | L | -11 |
| 11 | 2022-12-10 | Lafayette (298) | 63 | 76 | Quinnipiac (150) | Final | L | -13 |
| 12 | 2022-12-12 | Columbia (340) | 57 | 45 | Lafayette (298) | Final | L | -12 |
| 13 | 2022-12-21 | Lafayette (298) | 90 | 65 | La Salle (182) | Final | W | 25 |
| 14 | 2022-12-30 | American (248) | 60 | 47 | Lafayette (298) | Final | L | -13 |
| 15 | 2023-01-02 | Army (258) | 82 | 65 | Lafayette (298) | Final | L | -17 |
| 16 | 2023-01-05 | Lafayette (298) | 69 | 73 | Boston University (274) | Final | L | -4 |
| 17 | 2023-01-08 | Bucknell (305) | 67 | 74 | Lafayette (298) | Final | W | 7 |
| 18 | 2023-01-11 | Lafayette (298) | 59 | 50 | Navy (205) | Final | W | 9 |
| 19 | 2023-01-14 | Holy Cross (327) | 48 | 62 | Lafayette (298) | Final | W | 14 |
| 20 | 2023-01-18 | Lafayette (298) | 70 | 59 | American (248) | Final | W | 11 |
| 21 | 2023-01-21 | Lafayette (298) | 49 | 61 | Lehigh (243) | Final | L | -12 |
| 22 | 2023-01-25 | Loyola-Maryland (328) | 46 | 62 | Lafayette (298) | Final | W | 16 |
| 23 | 2023-01-28 | Lafayette (298) | 57 | 69 | Colgate (124) | Final | L | -12 |
| 24 | 2023-02-01 | Navy (205) | 53 | 34 | Lafayette (298) | Final | L | -19 |
| 25 | 2023-02-04 | Lehigh (243) | 66 | 64 | Lafayette (298) | Final | L | -2 |
| 26 | 2023-02-06 | Lafayette (298) | 72 | 58 | Holy Cross (327) | Final | W | 14 |
| 27 | 2023-02-11 | Boston University (274) | 65 | 69 | Lafayette (298) | Final | W | 4 |
| 28 | 2023-02-15 | Lafayette (298) | 70 | 73 | Loyola-Maryland (328) | Final | L | -3 |
| 29 | 2023-02-18 | Lafayette (298) | 43 | 53 | Army (258) | Final | L | -10 |
| 30 | 2023-02-22 | Colgate (122) | 73 | 69 | Lafayette (296) | Final | L | -4 |
| 31 | 2023-02-25 | Lafayette (310) | 65 | 75 | Bucknell (306) | Final | L | -10 |
| 32 | 2023-03-02 | Lafayette (305) | 71 | 64 | Lehigh (248) | Final | W | 7 |
| 33 | 2023-03-05 | American (260) | 76 | 84 | Lafayette (297) | Final | W | 8 |
| 34 | 2023-03-08 | Lafayette (296) | 61 | 79 | Colgate (118) | Final | L | -18 |