Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-11-07 | IUPUI (362) | 39 | 88 | Iowa State (20) | Final | W | 49 |
| 2 | 2022-11-13 | North Carolina A&T (280) | 43 | 80 | Iowa State (20) | Final | W | 37 |
| 3 | 2022-11-20 | Milwaukee (184) | 53 | 68 | Iowa State (20) | Final | W | 15 |
| 4 | 2022-11-24 | Iowa State (20) | 81 | 79 | Villanova (93) | Final | W | 2 |
| 5 | 2022-11-25 | North Carolina (47) | 65 | 70 | Iowa State (20) | Final | W | 5 |
| 6 | 2022-11-27 | Iowa State (20) | 53 | 71 | Connecticut (13) | Final | L | -18 |
| 7 | 2022-11-30 | North Dakota (251) | 44 | 63 | Iowa State (7) | Final | W | 19 |
| 8 | 2022-12-04 | St. John's (85) | 60 | 71 | Iowa State (20) | Final | W | 11 |
| 9 | 2022-12-08 | Iowa State (20) | 56 | 75 | Iowa (43) | Final | L | -19 |
| 10 | 2022-12-11 | McNeese State (334) | 40 | 77 | Iowa State (20) | Final | W | 37 |
| 11 | 2022-12-21 | Nebraska-Omaha (272) | 0 | 0 | Iowa State (7) | Canceled | - | - |
| 12 | 2022-12-31 | Baylor (9) | 62 | 77 | Iowa State (20) | Final | W | 15 |
| 13 | 2023-01-04 | Iowa State (20) | 63 | 60 | Oklahoma (62) | Final | W | 3 |
| 14 | 2023-01-07 | Iowa State (20) | 69 | 67 | TCU (23) | Final | W | 2 |
| 15 | 2023-01-10 | Texas Tech (52) | 50 | 84 | Iowa State (20) | Final | W | 34 |
| 16 | 2023-01-14 | Iowa State (20) | 60 | 62 | Kansas (3) | Final | L | -2 |
| 17 | 2023-01-17 | Texas (7) | 67 | 78 | Iowa State (20) | Final | W | 11 |
| 18 | 2023-01-21 | Iowa State (20) | 59 | 61 | Oklahoma State (44) | Final | L | -2 |
| 19 | 2023-01-24 | Kansas State (15) | 76 | 80 | Iowa State (20) | Final | W | 4 |
| 20 | 2023-01-28 | Iowa State (20) | 61 | 78 | Missouri (38) | Final | L | -17 |
| 21 | 2023-01-30 | Iowa State (20) | 77 | 80 | Texas Tech (52) | Final | L | -3 |
| 22 | 2023-02-04 | Kansas (3) | 53 | 68 | Iowa State (20) | Final | W | 15 |
| 23 | 2023-02-08 | Iowa State (20) | 71 | 76 | West Virginia (42) | Final | L | -5 |
| 24 | 2023-02-11 | Oklahoma State (57) | 64 | 56 | Iowa State (7) | Final | L | -8 |
| 25 | 2023-02-15 | TCU (32) | 59 | 70 | Iowa State (7) | Final | W | 11 |
| 26 | 2023-02-18 | Iowa State (7) | 55 | 61 | Kansas State (96) | Final | L | -6 |
| 27 | 2023-02-21 | Iowa State (20) | 54 | 72 | Texas (7) | Final | L | -18 |
| 28 | 2023-02-25 | Oklahoma (59) | 61 | 50 | Iowa State (26) | Final | L | -11 |
| 29 | 2023-02-27 | West Virginia (33) | 72 | 69 | Iowa State (31) | Final | L | -3 |
| 30 | 2023-03-04 | Iowa State (7) | 73 | 58 | Baylor (58) | Final | W | 15 |
| 31 | 2023-03-09 | Iowa State (25) | 78 | 72 | Baylor (12) | Final | W | 6 |
| 32 | 2023-03-10 | Iowa State (25) | 58 | 71 | Kansas (3) | Final | L | -13 |
| 33 | 2023-03-17 | Pittsburgh | 59 | 41 | Iowa State | Final | L | -18 |