Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-11-08 | Coppin State (346) | 89 | 99 | Georgetown (215) | Final | W | 10 |
| 2 | 2022-11-12 | Green Bay (360) | 58 | 92 | Georgetown (215) | Final | W | 34 |
| 3 | 2022-11-15 | Northwestern (24) | 75 | 63 | Georgetown (215) | Final | L | -12 |
| 4 | 2022-11-18 | Loyola Marymount (97) | 84 | 66 | Georgetown (215) | Final | L | -18 |
| 5 | 2022-11-20 | La Salle (182) | 62 | 69 | Georgetown (215) | Final | W | 7 |
| 6 | 2022-11-23 | American (248) | 74 | 70 | Georgetown (215) | Final | L | -4 |
| 7 | 2022-11-26 | UMBC (223) | 70 | 79 | Georgetown (215) | Final | W | 9 |
| 8 | 2022-11-30 | Georgetown (83) | 65 | 79 | Texas Tech (20) | Final | L | -14 |
| 9 | 2022-12-03 | South Carolina (110) | 74 | 71 | Georgetown (83) | Final/OT | L | -3 |
| 10 | 2022-12-07 | Siena (166) | 68 | 75 | Georgetown (215) | Final | W | 7 |
| 11 | 2022-12-10 | Georgetown (215) | 64 | 83 | Syracuse (87) | Final | L | -19 |
| 12 | 2022-12-16 | Xavier (92) | 102 | 89 | Georgetown (83) | Final | L | -13 |
| 13 | 2022-12-20 | Georgetown (215) | 73 | 84 | Connecticut (13) | Final | L | -11 |
| 14 | 2022-12-29 | Georgetown (83) | 76 | 83 | DePaul (95) | Final | L | -7 |
| 15 | 2023-01-01 | Butler (104) | 80 | 51 | Georgetown (215) | Final | L | -29 |
| 16 | 2023-01-04 | Villanova (93) | 73 | 57 | Georgetown (215) | Final | L | -16 |
| 17 | 2023-01-07 | Georgetown (215) | 73 | 95 | Marquette (14) | Final | L | -22 |
| 18 | 2023-01-10 | Seton Hall (73) | 66 | 51 | Georgetown (215) | Final | L | -15 |
| 19 | 2023-01-16 | Georgetown (215) | 73 | 77 | Villanova (93) | Final | L | -4 |
| 20 | 2023-01-21 | Georgetown (215) | 82 | 95 | Xavier (18) | Final | L | -13 |
| 21 | 2023-01-24 | DePaul (159) | 76 | 81 | Georgetown (215) | Final | W | 5 |
| 22 | 2023-01-29 | Georgetown (215) | 73 | 75 | St. John's (85) | Final | L | -2 |
| 23 | 2023-02-01 | Creighton (21) | 63 | 53 | Georgetown (215) | Final | L | -10 |
| 24 | 2023-02-04 | Connecticut (13) | 68 | 62 | Georgetown (215) | Final | L | -6 |
| 25 | 2023-02-08 | Georgetown (215) | 62 | 74 | Providence (31) | Final | L | -12 |
| 26 | 2023-02-11 | Marquette (106) | 89 | 75 | Georgetown (83) | Final | L | -14 |
| 27 | 2023-02-14 | Georgetown (215) | 68 | 76 | Seton Hall (73) | Final | L | -8 |
| 28 | 2023-02-19 | Georgetown (215) | 68 | 62 | Butler (104) | Final | W | 6 |
| 29 | 2023-02-22 | St. John's (12) | 79 | 70 | Georgetown (83) | Final | L | -9 |
| 30 | 2023-02-26 | Providence (38) | 88 | 68 | Georgetown (226) | Final | L | -20 |
| 31 | 2023-03-01 | Georgetown (83) | 59 | 99 | Creighton (78) | Final | L | -40 |
| 32 | 2023-03-08 | Georgetown (232) | 48 | 80 | Villanova (74) | Final | L | -32 |