Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-11-07 | St. Thomas (178) | 60 | 72 | Creighton (21) | Final | W | 12 |
| 2 | 2022-11-10 | North Dakota (285) | 61 | 96 | Creighton (21) | Final | W | 35 |
| 3 | 2022-11-14 | Holy Cross (334) | 65 | 94 | Creighton (78) | Final | W | 29 |
| 4 | 2022-11-17 | UC-Riverside (129) | 51 | 80 | Creighton (21) | Final | W | 29 |
| 5 | 2022-11-21 | Texas Tech (52) | 65 | 76 | Creighton (21) | Final | W | 11 |
| 6 | 2022-11-22 | Creighton (21) | 90 | 87 | Arkansas (22) | Final | W | 3 |
| 7 | 2022-11-23 | Creighton (21) | 79 | 81 | Arizona (6) | Final | L | -2 |
| 8 | 2022-12-01 | Creighton (21) | 67 | 72 | Texas (7) | Final | L | -5 |
| 9 | 2022-12-04 | Nebraska (83) | 63 | 53 | Creighton (21) | Final | L | -10 |
| 10 | 2022-12-10 | Creighton (21) | 80 | 83 | BYU (107) | Final | L | -3 |
| 11 | 2022-12-12 | Arizona State (58) | 73 | 71 | Creighton (21) | Final | L | -2 |
| 12 | 2022-12-16 | Creighton (78) | 58 | 69 | Marquette (106) | Final | L | -11 |
| 13 | 2022-12-22 | Butler (80) | 56 | 78 | Creighton (78) | Final | W | 22 |
| 14 | 2022-12-25 | DePaul (159) | 65 | 80 | Creighton (21) | Final | W | 15 |
| 15 | 2023-01-03 | Seton Hall (73) | 61 | 83 | Creighton (21) | Final | W | 22 |
| 16 | 2023-01-07 | Creighton (21) | 60 | 69 | Connecticut (13) | Final | L | -9 |
| 17 | 2023-01-11 | Creighton (21) | 87 | 90 | Xavier (18) | Final | L | -3 |
| 18 | 2023-01-14 | Providence (31) | 67 | 73 | Creighton (21) | Final | W | 6 |
| 19 | 2023-01-17 | Creighton (21) | 73 | 52 | Butler (104) | Final | W | 21 |
| 20 | 2023-01-25 | St. John's (85) | 76 | 104 | Creighton (21) | Final | W | 28 |
| 21 | 2023-01-28 | Xavier (18) | 67 | 84 | Creighton (21) | Final | W | 17 |
| 22 | 2023-02-01 | Creighton (21) | 63 | 53 | Georgetown (215) | Final | W | 10 |
| 23 | 2023-02-04 | Villanova (93) | 61 | 66 | Creighton (21) | Final | W | 5 |
| 24 | 2023-02-08 | Creighton (21) | 75 | 62 | Seton Hall (73) | Final | W | 13 |
| 25 | 2023-02-11 | Connecticut (4) | 53 | 56 | Creighton (78) | Final | W | 3 |
| 26 | 2023-02-14 | Creighton (21) | 86 | 94 | Providence (31) | Final | L | -8 |
| 27 | 2023-02-18 | Creighton (78) | 77 | 67 | St. John's (12) | Final | W | 10 |
| 28 | 2023-02-21 | Marquette (14) | 73 | 71 | Creighton (21) | Final | L | -2 |
| 29 | 2023-02-25 | Creighton (33) | 67 | 79 | Villanova (79) | Final | L | -12 |
| 30 | 2023-03-01 | Georgetown (83) | 59 | 99 | Creighton (78) | Final | W | 40 |
| 31 | 2023-03-04 | Creighton (78) | 84 | 70 | DePaul (95) | Final | W | 14 |
| 32 | 2023-03-09 | Villanova (77) | 74 | 87 | Creighton (27) | Final | W | 13 |
| 33 | 2023-03-10 | Creighton (27) | 60 | 82 | Xavier (18) | Final | L | -22 |
| 34 | 2023-03-17 | North Carolina State | 63 | 72 | Creighton | Final | W | 9 |
| 35 | 2023-03-19 | Creighton (31) | 85 | 76 | Baylor (12) | Final | W | 9 |
| 36 | 2023-03-24 | Princeton (117) | 75 | 86 | Creighton (31) | Final | W | 11 |
| 37 | 2023-03-26 | Creighton (31) | 56 | 57 | San Diego State (13) | Final | L | -1 |