Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2024-11-04 | Charleston Southern (262) | 64 | 91 | Clemson (36) | Final | W | 27 |
| 2 | 2024-11-08 | Saint Francis (355) | 62 | 88 | Clemson (40) | Final | W | 26 |
| 3 | 2024-11-12 | Eastern Kentucky (180) | 62 | 75 | Clemson (15) | Final | W | 13 |
| 4 | 2024-11-17 | Clemson (106) | 71 | 84 | Boise State (81) | Final | L | -13 |
| 5 | 2024-11-21 | Radford (145) | 51 | 79 | Clemson (69) | Final | W | 28 |
| 6 | 2024-11-25 | Clemson (46) | 70 | 55 | San Francisco (81) | Final | W | 15 |
| 7 | 2024-11-26 | Clemson (20) | 75 | 67 | Penn State (29) | Final | W | 8 |
| 8 | 2024-11-29 | Florida A&M (322) | 58 | 86 | Clemson (27) | Final | W | 28 |
| 9 | 2024-12-03 | Kentucky (15) | 66 | 70 | Clemson (13) | Final | W | 4 |
| 10 | 2024-12-07 | Clemson (11) | 65 | 55 | Miami (198) | Final | W | 10 |
| 11 | 2024-12-14 | Memphis (13) | 87 | 82 | Clemson (22) | Final (OT) | L | -5 |
| 12 | 2024-12-17 | Clemson (36) | 88 | 91 | South Carolina (78) | Final (OT) | L | -3 |
| 13 | 2024-12-21 | Wake Forest (83) | 62 | 73 | Clemson (37) | Final | W | 11 |
| 14 | 2025-01-01 | Stanford (80) | 71 | 85 | Clemson (30) | Final | W | 14 |
| 15 | 2025-01-04 | California (119) | 68 | 80 | Clemson (29) | Final | W | 12 |
| 16 | 2025-01-07 | Clemson (37) | 64 | 74 | Louisville (26) | Final | L | -10 |
| 17 | 2025-01-11 | Florida State (68) | 57 | 77 | Clemson (35) | Final | W | 20 |
| 18 | 2025-01-14 | Clemson (31) | 70 | 59 | Georgia Tech (146) | Final | W | 11 |
| 19 | 2025-01-18 | Clemson (27) | 78 | 75 | Pittsburgh (32) | Final (OT) | W | 3 |
| 20 | 2025-01-22 | Syracuse (118) | 72 | 86 | Clemson (25) | Final | W | 14 |
| 21 | 2025-01-25 | Clemson (26) | 72 | 57 | Virginia Tech (162) | Final | W | 15 |
| 22 | 2025-02-01 | Clemson (27) | 68 | 58 | North Carolina State (119) | Final | W | 10 |
| 23 | 2025-02-04 | Georgia Tech (113) | 89 | 86 | Clemson (34) | Final (3OT) | L | -3 |
| 24 | 2025-02-08 | Duke (5) | 71 | 77 | Clemson (28) | Final | W | 6 |
| 25 | 2025-02-10 | North Carolina (49) | 65 | 85 | Clemson (26) | Final | W | 20 |
| 26 | 2025-02-15 | Clemson (21) | 72 | 46 | Florida State (85) | Final | W | 26 |
| 27 | 2025-02-22 | Clemson (18) | 79 | 69 | SMU (39) | Final | W | 10 |
| 28 | 2025-02-26 | Notre Dame (121) | 68 | 83 | Clemson (14) | Final | W | 15 |
| 29 | 2025-03-01 | Clemson (36) | 71 | 58 | Virginia (14) | Final | W | 13 |
| 30 | 2025-03-05 | Clemson (16) | 78 | 69 | Boston College (169) | Final | W | 9 |
| 31 | 2025-03-08 | Virginia Tech (137) | 47 | 65 | Clemson (14) | Final | W | 18 |
| 32 | 2025-03-13 | SMU (49) | 54 | 57 | Clemson (14) | Final | W | 3 |
| 33 | 2025-03-14 | Clemson (11) | 73 | 76 | Louisville (13) | Final | L | -3 |
| 34 | 2025-03-20 | McNeese (65) | 69 | 67 | Clemson (15) | Final | L | -2 |