NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-25 | Rider (339) | 37 | 70 | Villanova (35) | Final | W | 33 |
| 2 | 2020-11-28 | Villanova (35) | 0 | 0 | Manhattan (296) | Cancelled | - | - |
| 3 | 2020-11-29 | Villanova (35) | 63 | 60 | Quinnipiac (99) | Final | W | 3 |
| 4 | 2020-12-04 | DePaul (104) | Villanova (12) | Cancelled | - | - | ||
| 5 | 2020-12-04 | Villanova (35) | 90 | 72 | Temple (151) | Final | W | 18 |
| 6 | 2020-12-06 | Villanova (35) | 74 | 65 | St. John's (87) | Final | W | 9 |
| 7 | 2020-12-09 | La Salle (219) | 52 | 78 | Villanova (10) | Final | W | 26 |
| 8 | 2020-12-13 | Drexel (168) | 46 | 48 | Villanova (35) | Final | W | 2 |
| 9 | 2020-12-16 | Villanova (35) | 0 | 0 | Providence (147) | Postponed | - | - |
| 10 | 2020-12-19 | Creighton (98) | 68 | 73 | Villanova (35) | Final | W | 5 |
| 11 | 2020-12-22 | Connecticut (2) | 90 | 52 | Villanova (35) | Final | L | -38 |
| 12 | 2021-01-02 | Georgetown (119) | 0 | 0 | Villanova (35) | Cancelled | - | - |
| 13 | 2021-01-04 | Villanova (35) | 82 | 94 | DePaul (229) | Final | L | -12 |
| 14 | 2021-01-06 | Villanova (35) | 78 | 71 | Seton Hall (70) | Final | W | 7 |
| 15 | 2021-01-09 | Villanova (48) | Marquette (40) | Postponed | - | - | ||
| 16 | 2021-01-09 | Xavier (190) | 0 | 0 | Villanova (35) | Postponed | - | - |
| 17 | 2021-01-13 | Providence (180) | 0 | 0 | Villanova (41) | Postponed | - | - |
| 18 | 2021-01-16 | Villanova (35) | 0 | 0 | Connecticut (2) | Postponed | - | - |
| 19 | 2021-01-20 | DePaul (229) | 0 | 0 | Villanova (35) | Cancelled | - | - |
| 20 | 2021-01-25 | St. John's (180) | 78 | 81 | Villanova (41) | Final/OT | W | 3 |
| 21 | 2021-01-27 | Villanova (39) | Xavier (183) | Cancelled | - | - | ||
| 22 | 2021-01-27 | Marquette (83) | 95 | 77 | Villanova (35) | Final | L | -18 |
| 23 | 2021-01-30 | Seton Hall (70) | 0 | 0 | Villanova (35) | Postponed | - | - |
| 24 | 2021-01-31 | Villanova (35) | 90 | 53 | Butler (157) | Final | W | 37 |
| 25 | 2021-02-03 | Providence (147) | 53 | 67 | Villanova (35) | Final | W | 14 |
| 26 | 2021-02-06 | Villanova (35) | 0 | 0 | Creighton (98) | Cancelled | - | - |
| 27 | 2021-02-08 | Villanova (48) | 0 | 0 | Providence (178) | Postponed | - | - |
| 28 | 2021-02-10 | Xavier (186) | 0 | 0 | Villanova (43) | Postponed | - | - |
| 29 | 2021-02-12 | Villanova (35) | 0 | 0 | DePaul (229) | Cancelled | - | - |
| 30 | 2021-02-16 | Butler (318) | 74 | 98 | Villanova (46) | Final | W | 24 |
| 31 | 2021-02-19 | Villanova (35) | 57 | 65 | Marquette (83) | Final | L | -8 |
| 32 | 2021-02-21 | Villanova (35) | 64 | 56 | Georgetown (119) | Final | W | 8 |
| 33 | 2021-02-24 | Villanova (35) | 63 | 58 | Providence (147) | Final/OT | W | 5 |
| 34 | 2021-02-27 | Marquette (49) | Villanova (43) | Cancelled | - | - | ||
| 35 | 2021-02-27 | Seton Hall (70) | 67 | 55 | Villanova (35) | Final | L | -12 |
| 36 | 2021-03-06 | Villanova (35) | 78 | 72 | DePaul (229) | Final/OT | W | 6 |
| 37 | 2021-03-07 | Villanova (59) | 39 | 84 | Connecticut (1) | Final | L | -45 |
| 38 | 2021-03-19 | Massachusetts (86) | 51 | 78 | Villanova (53) | Final | W | 27 |
| 39 | 2021-03-20 | Florida (77) | 57 | 77 | Villanova (53) | Final | W | 20 |
| 40 | 2021-03-22 | Delaware (57) | 77 | 70 | Villanova (53) | Final | L | -7 |