NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-25 | Massachusetts (95) | 82 | 54 | Bryant (184) | Final | W | 28 |
| 2 | 2020-11-28 | Massachusetts (95) | 0 | 0 | UMass-Lowell (330) | Cancelled | - | - |
| 3 | 2020-11-29 | Massachusetts (95) | 82 | 90 | Boston College (259) | Final/OT | L | -8 |
| 4 | 2020-12-03 | Massachusetts (95) | 71 | 50 | Fairfield (50) | Final | W | 21 |
| 5 | 2020-12-08 | Rhode Island (41) | 69 | 79 | Massachusetts (95) | Final | W | 10 |
| 6 | 2020-12-10 | Massachusetts (95) | 74 | 55 | New Hampshire (283) | Final | W | 19 |
| 7 | 2020-12-13 | St. John's (87) | 61 | 63 | Massachusetts (95) | Final | W | 2 |
| 8 | 2021-01-01 | Massachusetts (95) | 0 | 0 | Saint Joseph's (92) | Cancelled | - | - |
| 9 | 2021-01-03 | Massachusetts (95) | 78 | 61 | La Salle (143) | Final | W | 17 |
| 10 | 2021-01-05 | Rhode Island (41) | 48 | 47 | Massachusetts (95) | Final | L | -1 |
| 11 | 2021-01-08 | Davidson (79) | 61 | 82 | Massachusetts (95) | Final | W | 21 |
| 12 | 2021-01-10 | Fordham (261) | 56 | 61 | Massachusetts (95) | Final | W | 5 |
| 13 | 2021-01-15 | Massachusetts (95) | 55 | 49 | Virginia Commonwealth (235) | Final | W | 6 |
| 14 | 2021-01-17 | Massachusetts (52) | Richmond (178) | Cancelled | - | - | ||
| 15 | 2021-01-17 | Massachusetts (95) | 0 | 0 | Virginia Commonwealth (235) | Cancelled | - | - |
| 16 | 2021-01-22 | Massachusetts (50) | Dayton (86) | Postponed | - | - | ||
| 17 | 2021-01-22 | Massachusetts (95) | 78 | 62 | Saint Louis (206) | Final | W | 16 |
| 18 | 2021-01-24 | Massachusetts (95) | 52 | 63 | Saint Louis (206) | Final | L | -11 |
| 19 | 2021-01-29 | Saint Joseph's (92) | 76 | 69 | Massachusetts (95) | Final | L | -7 |
| 20 | 2021-01-31 | La Salle (143) | 69 | 63 | Massachusetts (95) | Final | L | -6 |
| 21 | 2021-02-05 | George Washington (160) | 0 | 0 | Massachusetts (95) | Cancelled | - | - |
| 22 | 2021-02-07 | George Mason (57) | 0 | 0 | Massachusetts (95) | Cancelled | - | - |
| 23 | 2021-02-14 | Massachusetts (95) | 0 | 0 | Rhode Island (41) | Postponed | - | - |
| 24 | 2021-02-18 | Massachusetts (95) | 0 | 0 | St. Bonaventure (195) | Cancelled | - | - |
| 25 | 2021-02-20 | Massachusetts (87) | Duquesne (227) | Postponed | - | - | ||
| 26 | 2021-02-26 | Virginia Commonwealth (235) | 72 | 69 | Massachusetts (95) | Final | L | -3 |
| 27 | 2021-02-28 | Richmond (43) | 65 | 70 | Massachusetts (95) | Final | W | 5 |
| 28 | 2021-03-11 | Saint Joseph's (202) | 69 | 79 | Massachusetts (93) | Final/OT | W | 10 |
| 29 | 2021-03-12 | Massachusetts (93) | 80 | 70 | Fordham (72) | Final | W | 10 |
| 30 | 2021-03-13 | Massachusetts (95) | 90 | 81 | Saint Louis (206) | Final | W | 9 |
| 31 | 2021-03-14 | Massachusetts (93) | 69 | 81 | Virginia Commonwealth (141) | Final | L | -12 |
| 32 | 2021-03-19 | Massachusetts (86) | 51 | 78 | Villanova (53) | Final | L | -27 |
| 33 | 2021-03-20 | Charlotte (126) | 75 | 81 | Massachusetts (86) | Final | W | 6 |
| 34 | 2021-03-22 | Ohio (87) | 71 | 95 | Massachusetts (86) | Final | W | 24 |