NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-28 | Iowa State (37) | 69 | 76 | South Dakota State (42) | Final | W | 7 |
| 2 | 2020-11-30 | Creighton (98) | 47 | 66 | South Dakota State (42) | Final | W | 19 |
| 3 | 2020-12-06 | Gonzaga (65) | 72 | 75 | South Dakota State (42) | Final/OT | W | 3 |
| 4 | 2020-12-10 | South Dakota State (42) | 53 | 62 | Kansas State (62) | Final | L | -9 |
| 5 | 2020-12-12 | South Dakota State (42) | 48 | 65 | Northern Iowa (132) | Final | L | -17 |
| 6 | 2020-12-15 | Drake (236) | 73 | 87 | South Dakota State (42) | Final | W | 14 |
| 7 | 2020-12-19 | South Dakota State (42) | 60 | 52 | Missouri State (110) | Final | W | 8 |
| 8 | 2020-12-21 | South Dakota State (42) | 82 | 67 | Montana State (76) | Final | W | 15 |
| 9 | 2020-12-23 | Northern Iowa (132) | 63 | 74 | South Dakota State (42) | Final | W | 11 |
| 10 | 2021-01-08 | Western Illinois (91) | 61 | 71 | South Dakota State (42) | Final | W | 10 |
| 11 | 2021-01-09 | Western Illinois (91) | 66 | 87 | South Dakota State (42) | Final | W | 21 |
| 12 | 2021-01-15 | South Dakota State (42) | 62 | 50 | Nebraska-Omaha (345) | Final | W | 12 |
| 13 | 2021-01-16 | South Dakota State (42) | 64 | 54 | Nebraska-Omaha (345) | Final | W | 10 |
| 14 | 2021-01-22 | North Dakota (332) | 52 | 81 | South Dakota State (42) | Final | W | 29 |
| 15 | 2021-01-23 | North Dakota (332) | 44 | 66 | South Dakota State (42) | Final | W | 22 |
| 16 | 2021-01-29 | South Dakota State (42) | 0 | 0 | Denver (269) | Cancelled | - | - |
| 17 | 2021-01-30 | South Dakota State (42) | 0 | 0 | Denver (269) | Cancelled | - | - |
| 18 | 2021-02-05 | South Dakota (112) | 45 | 64 | South Dakota State (42) | Final | W | 19 |
| 19 | 2021-02-06 | South Dakota (112) | 75 | 80 | South Dakota State (42) | Final | W | 5 |
| 20 | 2021-02-13 | South Dakota State (42) | 82 | 60 | Oral Roberts (203) | Final | W | 22 |
| 21 | 2021-02-14 | South Dakota State (42) | 73 | 61 | Oral Roberts (203) | Final | W | 12 |
| 22 | 2021-02-19 | South Dakota State (42) | 86 | 78 | North Dakota State (59) | Final | W | 8 |
| 23 | 2021-02-20 | South Dakota State (42) | 69 | 60 | North Dakota State (59) | Final | W | 9 |
| 24 | 2021-02-26 | UMKC (309) | 53 | 73 | South Dakota State (42) | Final | W | 20 |
| 25 | 2021-02-27 | UMKC (309) | 66 | 72 | South Dakota State (42) | Final | W | 6 |
| 26 | 2021-03-06 | Nebraska-Omaha (345) | 52 | 40 | South Dakota State (42) | Final | L | -12 |
| 27 | 2021-03-21 | South Dakota State (29) | 55 | 72 | Syracuse (39) | Final | L | -17 |