NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-25 | Nebraska-Omaha (345) | 43 | 69 | Iowa State (37) | Final | W | 26 |
| 2 | 2020-11-28 | Iowa State (37) | 69 | 76 | South Dakota State (42) | Final | L | -7 |
| 3 | 2020-12-02 | Iowa State (37) | 91 | 68 | TCU (12) | Final | W | 23 |
| 4 | 2020-12-06 | South Carolina (3) | 83 | 65 | Iowa State (37) | Final | L | -18 |
| 5 | 2020-12-09 | Iowa State (66) | 80 | 82 | Iowa (24) | Final | L | -2 |
| 6 | 2020-12-12 | North Dakota State (59) | 64 | 85 | Iowa State (37) | Final | W | 21 |
| 7 | 2020-12-15 | Iowa State (37) | 67 | 61 | Northern Iowa (132) | Final | W | 6 |
| 8 | 2020-12-18 | Kansas State (62) | 69 | 91 | Iowa State (37) | Final | W | 22 |
| 9 | 2020-12-22 | Drake (236) | 67 | 85 | Iowa State (37) | Final | W | 18 |
| 10 | 2021-01-03 | Iowa State (37) | 59 | 74 | Texas (4) | Final | L | -15 |
| 11 | 2021-01-06 | Kansas (49) | 0 | 0 | Iowa State (37) | Postponed | - | - |
| 12 | 2021-01-10 | Iowa State (37) | 99 | 72 | Texas Tech (26) | Final | W | 27 |
| 13 | 2021-01-13 | Oklahoma State (28) | 80 | 90 | Iowa State (38) | Final | W | 10 |
| 14 | 2021-01-16 | Iowa State (37) | 75 | 71 | Baylor (24) | Final | W | 4 |
| 15 | 2021-01-19 | Oklahoma (10) | 63 | 64 | Iowa State (37) | Final | W | 1 |
| 16 | 2021-01-23 | Texas (4) | 70 | 59 | Iowa State (37) | Final | L | -11 |
| 17 | 2021-01-28 | Iowa State (37) | 62 | 60 | Kansas State (62) | Final | W | 2 |
| 18 | 2021-01-31 | Baylor (24) | 85 | 77 | Iowa State (37) | Final | L | -8 |
| 19 | 2021-02-03 | Iowa State (37) | 56 | 65 | West Virginia (15) | Final | L | -9 |
| 20 | 2021-02-06 | Texas Tech (26) | 73 | 92 | Iowa State (37) | Final | W | 19 |
| 21 | 2021-02-09 | Iowa State (30) | 61 | 67 | Oklahoma (90) | Final | L | -6 |
| 22 | 2021-02-13 | TCU (12) | 81 | 92 | Iowa State (37) | Final | W | 11 |
| 23 | 2021-02-17 | Iowa State (37) | 84 | 82 | Kansas (49) | Final | W | 2 |
| 24 | 2021-02-20 | Iowa State (37) | 73 | 80 | Oklahoma State (32) | Final | L | -7 |
| 25 | 2021-02-24 | West Virginia (15) | 68 | 85 | Iowa State (37) | Final | W | 17 |
| 26 | 2021-03-03 | Kansas (49) | 53 | 83 | Iowa State (37) | Final | W | 30 |
| 27 | 2021-03-12 | Texas (27) | 84 | 82 | Iowa State (31) | Final/OT | L | -2 |
| 28 | 2021-03-22 | Michigan State (40) | 75 | 79 | Iowa State (32) | Final | W | 4 |
| 29 | 2021-03-24 | Iowa State (32) | 82 | 84 | Texas A&M (4) | Final/OT | L | -2 |