NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-28 | South Dakota (112) | 71 | 81 | South Carolina (3) | Final | L | -10 |
| 2 | 2020-11-30 | South Dakota (10) | Oklahoma (81) | Cancelled | - | - | ||
| 3 | 2020-11-30 | Gonzaga (65) | 54 | 50 | South Dakota (112) | Final | L | -4 |
| 4 | 2020-12-06 | Lipscomb (286) | 52 | 89 | South Dakota (112) | Final | W | 37 |
| 5 | 2020-12-10 | South Dakota (112) | 62 | 54 | Wichita State (266) | Final | W | 8 |
| 6 | 2020-12-17 | South Dakota (112) | 84 | 68 | Bradley (155) | Final | W | 16 |
| 7 | 2020-12-20 | South Dakota (96) | 73 | 80 | Oklahoma (223) | Final | L | -7 |
| 8 | 2020-12-30 | Midland | 39 | 89 | South Dakota (112) | Final | W | 50 |
| 9 | 2021-01-02 | Denver (269) | 47 | 87 | South Dakota (112) | Final | W | 40 |
| 10 | 2021-01-03 | Denver (269) | 74 | 89 | South Dakota (112) | Final | W | 15 |
| 11 | 2021-01-08 | South Dakota (112) | 92 | 34 | UMKC (309) | Final | W | 58 |
| 12 | 2021-01-09 | South Dakota (112) | 80 | 53 | UMKC (309) | Final | W | 27 |
| 13 | 2021-01-22 | South Dakota (112) | 73 | 56 | Western Illinois (91) | Final | W | 17 |
| 14 | 2021-01-23 | South Dakota (112) | 61 | 56 | Western Illinois (91) | Final | W | 5 |
| 15 | 2021-01-29 | Nebraska-Omaha (345) | 0 | 0 | South Dakota (112) | Cancelled | - | - |
| 16 | 2021-01-30 | Nebraska-Omaha (345) | 0 | 0 | South Dakota (112) | Cancelled | - | - |
| 17 | 2021-02-05 | South Dakota (112) | 45 | 64 | South Dakota State (42) | Final | L | -19 |
| 18 | 2021-02-06 | South Dakota (112) | 75 | 80 | South Dakota State (42) | Final | L | -5 |
| 19 | 2021-02-13 | South Dakota (112) | 72 | 63 | North Dakota (332) | Final | W | 9 |
| 20 | 2021-02-14 | South Dakota (112) | 64 | 47 | North Dakota (332) | Final | W | 17 |
| 21 | 2021-02-20 | Oral Roberts (203) | 54 | 77 | South Dakota (112) | Final | W | 23 |
| 22 | 2021-02-21 | Oral Roberts (203) | 54 | 76 | South Dakota (112) | Final | W | 22 |
| 23 | 2021-02-27 | North Dakota State (59) | 81 | 82 | South Dakota (112) | Final | W | 1 |
| 24 | 2021-02-28 | North Dakota State (59) | 61 | 81 | South Dakota (112) | Final | W | 20 |
| 25 | 2021-03-06 | Oral Roberts (203) | 66 | 89 | South Dakota (112) | Final | W | 23 |
| 26 | 2021-03-08 | North Dakota State (122) | 55 | 81 | South Dakota (51) | Final | W | 26 |
| 27 | 2021-03-09 | Nebraska-Omaha (245) | 43 | 66 | South Dakota (48) | Final | W | 23 |
| 28 | 2021-03-22 | South Dakota (45) | 47 | 67 | Oregon (33) | Final | L | -20 |