NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-10 | Cal Poly (169) | 77 | 91 | Santa Clara (139) | Final | W | 14 |
| 2 | 2021-11-14 | Nevada (176) | 60 | 73 | Santa Clara (139) | Final | W | 13 |
| 3 | 2021-11-17 | Santa Clara (64) | 67 | 58 | San Jose State (263) | Final | W | 9 |
| 4 | 2021-11-21 | Santa Clara (64) | 50 | 66 | Long Beach State (118) | Final | L | -16 |
| 5 | 2021-11-27 | Cal State-Bakersfield (257) | 53 | 67 | Santa Clara (105) | Final | W | 14 |
| 6 | 2021-11-29 | UC-Riverside (206) | 0 | 0 | Santa Clara (105) | Cancelled | - | - |
| 7 | 2021-12-01 | UC-Merced | 52 | 91 | Santa Clara (92) | Final | W | 39 |
| 8 | 2021-12-12 | Santa Clara (109) | 65 | 80 | Kansas (17) | Final | L | -15 |
| 9 | 2021-12-14 | Santa Clara (130) | 62 | 69 | UMKC (65) | Final | L | -7 |
| 10 | 2021-12-18 | California Baptist (130) | 58 | 54 | Santa Clara (86) | Final | L | -4 |
| 11 | 2021-12-20 | Holy Names | 30 | 88 | Santa Clara (139) | Final | W | 58 |
| 12 | 2021-12-30 | Saint Mary's (132) | 0 | 0 | Santa Clara (150) | Postponed | - | - |
| 13 | 2022-01-01 | Santa Clara (150) | 0 | 0 | San Francisco (133) | Postponed | - | - |
| 14 | 2022-01-06 | Santa Clara (150) | 0 | 0 | Pacific (287) | Postponed | - | - |
| 15 | 2022-01-08 | Santa Clara (86) | 0 | 0 | Gonzaga (65) | Postponed | - | - |
| 16 | 2022-01-13 | Pepperdine (146) | 64 | 74 | Santa Clara (86) | Final | W | 10 |
| 17 | 2022-01-15 | San Francisco (151) | 78 | 83 | Santa Clara (157) | Final | W | 5 |
| 18 | 2022-01-20 | Loyola Marymount (240) | 51 | 62 | Santa Clara (130) | Final | W | 11 |
| 19 | 2022-01-22 | Santa Clara (130) | 71 | 76 | Portland (62) | Final/OT | L | -5 |
| 20 | 2022-01-27 | Santa Clara (86) | 44 | 76 | BYU (45) | Final | L | -32 |
| 21 | 2022-01-29 | Pacific (278) | 64 | 75 | Santa Clara (133) | Final | W | 11 |
| 22 | 2022-01-31 | Santa Clara (86) | 69 | 74 | Pacific (227) | Final | L | -5 |
| 23 | 2022-02-03 | Santa Clara (156) | 73 | 78 | Saint Mary's (159) | Final | L | -5 |
| 24 | 2022-02-05 | San Diego (260) | 84 | 89 | Santa Clara (86) | Final | W | 5 |
| 25 | 2022-02-07 | Saint Mary's (223) | 88 | 81 | Santa Clara (86) | Final | L | -7 |
| 26 | 2022-02-10 | Gonzaga (65) | 72 | 55 | Santa Clara (86) | Final | L | -17 |
| 27 | 2022-02-12 | Santa Clara (146) | 62 | 61 | Loyola Marymount (235) | Final | W | 1 |
| 28 | 2022-02-17 | Santa Clara (162) | 63 | 54 | Pepperdine (242) | Final | W | 9 |
| 29 | 2022-02-19 | Portland (70) | 66 | 76 | Santa Clara (162) | Final | W | 10 |
| 30 | 2022-02-21 | Santa Clara (162) | 58 | 74 | Gonzaga (33) | Final | L | -16 |
| 31 | 2022-02-24 | BYU (13) | 103 | 66 | Santa Clara (142) | Final | L | -37 |
| 32 | 2022-02-26 | Santa Clara (142) | 66 | 73 | San Diego (117) | Final/OT | L | -7 |
| 33 | 2022-03-03 | Pacific (273) | 69 | 93 | Santa Clara (157) | Final | W | 24 |
| 34 | 2022-03-04 | Santa Clara (157) | 86 | 79 | San Diego (104) | Final | W | 7 |
| 35 | 2022-03-05 | Santa Clara (157) | 63 | 72 | San Francisco (119) | Final | L | -9 |