NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Hawaii (182) | 53 | 86 | San Diego (122) | Final | W | 33 |
| 2 | 2021-11-12 | San Diego (260) | 51 | 57 | Washington (23) | Final | L | -6 |
| 3 | 2021-11-14 | San Diego (122) | 66 | 46 | Idaho (106) | Final | W | 20 |
| 4 | 2021-11-17 | Air Force (124) | 46 | 52 | San Diego (108) | Final | W | 6 |
| 5 | 2021-11-26 | Fresno State (208) | 64 | 68 | San Diego (260) | Final | W | 4 |
| 6 | 2021-11-27 | Nebraska (16) | 64 | 56 | San Diego (81) | Final | L | -8 |
| 7 | 2021-12-01 | San Diego (96) | 63 | 51 | San Diego State (172) | Final | W | 12 |
| 8 | 2021-12-05 | San Diego (96) | 83 | 70 | Cal State-Northridge (256) | Final/OT | W | 13 |
| 9 | 2021-12-11 | San Diego (82) | 75 | 64 | UC-Irvine (162) | Final | W | 11 |
| 10 | 2021-12-18 | Arizona State (46) | 79 | 60 | San Diego (260) | Final | L | -19 |
| 11 | 2021-12-19 | Texas (4) | 74 | 58 | San Diego (260) | Final | L | -16 |
| 12 | 2021-12-21 | Texas State (268) | 58 | 78 | San Diego (97) | Final | W | 20 |
| 13 | 2021-12-30 | San Diego (94) | 0 | 0 | BYU (22) | Postponed | - | - |
| 14 | 2022-01-01 | San Diego (94) | 0 | 0 | Pacific (290) | Postponed | - | - |
| 15 | 2022-01-06 | Pepperdine (225) | 0 | 0 | San Diego (92) | Postponed | - | - |
| 16 | 2022-01-08 | San Francisco (152) | 56 | 65 | San Diego (260) | Final | W | 9 |
| 17 | 2022-01-13 | San Diego (260) | 80 | 48 | Loyola Marymount (117) | Final | W | 32 |
| 18 | 2022-01-15 | San Diego (81) | 66 | 76 | Gonzaga (47) | Final | L | -10 |
| 19 | 2022-01-20 | Saint Mary's (127) | 79 | 71 | San Diego (84) | Final | L | -8 |
| 20 | 2022-01-22 | BYU (14) | 74 | 63 | San Diego (84) | Final | L | -11 |
| 21 | 2022-01-24 | San Diego (84) | 48 | 70 | BYU (14) | Final | L | -22 |
| 22 | 2022-01-27 | Portland (138) | 68 | 55 | San Diego (260) | Final | L | -13 |
| 23 | 2022-01-29 | Gonzaga (34) | 69 | 43 | San Diego (97) | Final | L | -26 |
| 24 | 2022-02-03 | San Diego (106) | 48 | 61 | San Francisco (148) | Final | L | -13 |
| 25 | 2022-02-05 | San Diego (260) | 84 | 89 | Santa Clara (86) | Final | L | -5 |
| 26 | 2022-02-07 | San Diego (260) | 81 | 77 | Pacific (227) | Final | W | 4 |
| 27 | 2022-02-10 | Loyola Marymount (117) | 51 | 79 | San Diego (260) | Final | W | 28 |
| 28 | 2022-02-12 | San Diego (117) | 63 | 53 | Pepperdine (231) | Final | W | 10 |
| 29 | 2022-02-17 | Pacific (264) | 80 | 87 | San Diego (112) | Final | W | 7 |
| 30 | 2022-02-19 | San Diego (112) | 67 | 79 | Saint Mary's (146) | Final | L | -12 |
| 31 | 2022-02-21 | Pepperdine (242) | 0 | 0 | San Diego (112) | Canceled | - | - |
| 32 | 2022-02-24 | San Diego (117) | 61 | 53 | Portland (85) | Final | W | 8 |
| 33 | 2022-02-26 | Santa Clara (142) | 66 | 73 | San Diego (117) | Final/OT | W | 7 |
| 34 | 2022-03-04 | Santa Clara (157) | 86 | 79 | San Diego (104) | Final | L | -7 |
| 35 | 2022-03-17 | San Diego (111) | 76 | 67 | California Baptist (110) | Final | W | 9 |
| 36 | 2022-03-20 | San Diego (111) | 69 | 73 | New Mexico (99) | Final | L | -4 |