NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-27 | Saint Francis (359) | 44 | 77 | Michigan State (19) | Final | W | 33 |
| 2 | 2020-12-02 | Detroit (320) | 45 | 82 | Michigan State (19) | Final | W | 37 |
| 3 | 2020-12-09 | Michigan State (52) | 81 | 68 | Minnesota (230) | Final | W | 13 |
| 4 | 2020-12-12 | Iowa (9) | 82 | 86 | Michigan State (19) | Final | W | 4 |
| 5 | 2020-12-18 | Central Michigan (128) | 70 | 79 | Michigan State (19) | Final | W | 9 |
| 6 | 2020-12-20 | Northern Illinois (260) | 70 | 82 | Michigan State (23) | Final | W | 12 |
| 7 | 2020-12-22 | Oakland (262) | 56 | 94 | Michigan State (19) | Final | W | 38 |
| 8 | 2020-12-31 | Michigan State (19) | 0 | 0 | Ohio State (11) | Cancelled | - | - |
| 9 | 2021-01-03 | Michigan State (19) | 71 | 64 | Purdue (84) | Final | W | 7 |
| 10 | 2021-01-07 | Maryland (18) | 93 | 87 | Michigan State (19) | Final | L | -6 |
| 11 | 2021-01-10 | Nebraska (36) | 68 | 64 | Michigan State (19) | Final | L | -4 |
| 12 | 2021-01-14 | Michigan State (25) | 0 | 0 | Illinois (192) | Postponed | - | - |
| 13 | 2021-01-18 | Michigan State (25) | 0 | 0 | Michigan (7) | Postponed | - | - |
| 14 | 2021-01-21 | Indiana (53) | 0 | 0 | Michigan State (19) | Cancelled | - | - |
| 15 | 2021-01-24 | Michigan State (19) | 94 | 62 | Wisconsin (77) | Final | W | 32 |
| 16 | 2021-01-26 | Michigan (6) | 0 | 0 | Michigan State (27) | Postponed | - | - |
| 17 | 2021-01-28 | Michigan State (27) | Michigan (12) | Postponed | - | - | ||
| 18 | 2021-01-28 | Michigan State (19) | 52 | 92 | Maryland (18) | Final | L | -40 |
| 19 | 2021-01-31 | Michigan State (19) | 67 | 79 | Indiana (53) | Final | L | -12 |
| 20 | 2021-02-04 | Illinois (29) | 60 | 81 | Michigan State (19) | Final | W | 21 |
| 21 | 2021-02-07 | Northwestern (142) | 63 | 60 | Michigan State (19) | Final | L | -3 |
| 22 | 2021-02-10 | Michigan State (40) | 0 | 0 | Maryland (8) | Postponed | - | - |
| 23 | 2021-02-13 | Michigan State (19) | 78 | 65 | Penn State (96) | Final | W | 13 |
| 24 | 2021-02-16 | Michigan State (41) | 82 | 86 | Michigan (12) | Final | L | -4 |
| 25 | 2021-02-21 | Purdue (84) | 73 | 76 | Michigan State (19) | Final | W | 3 |
| 26 | 2021-02-24 | Rutgers (158) | 63 | 53 | Michigan State (19) | Final | L | -10 |
| 27 | 2021-02-27 | Michigan State (19) | 0 | 0 | Nebraska (36) | Cancelled | - | - |
| 28 | 2021-03-06 | Wisconsin (77) | 54 | 67 | Michigan State (19) | Final | W | 13 |
| 29 | 2021-03-10 | Penn State (94) | 66 | 75 | Michigan State (44) | Final | W | 9 |
| 30 | 2021-03-11 | Michigan State (44) | 69 | 61 | Indiana (10) | Final | W | 8 |
| 31 | 2021-03-12 | Michigan State (44) | 72 | 87 | Iowa (36) | Final | L | -15 |
| 32 | 2021-03-22 | Michigan State (40) | 75 | 79 | Iowa State (32) | Final | L | -4 |