Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2019-08-29 | Southern Illinois (212) | 26 | Southeast Missouri State (152) | 44 | Final | W | 18 |
| 2 | 2019-09-07 | Southeast Missouri State (152) | 17 | Montana State (146) | 38 | Final | L | -21 |
| 3 | 2019-09-14 | Southeast Missouri State (152) | 0 | Missouri (23) | 50 | Final | L | -50 |
| 4 | 2019-09-21 | West Virginia State | 10 | Southeast Missouri State | 56 | Final | W | 46 |
| 5 | 2019-10-05 | Tennessee Tech (145) | 37 | Southeast Missouri State (164) | 43 | Final(2OT) | W | 6 |
| 6 | 2019-10-12 | Southeast Missouri State (152) | 24 | Austin Peay (172) | 28 | Final | L | -4 |
| 7 | 2019-10-19 | Southeast Missouri State (175) | 24 | Jacksonville State (181) | 21 | Final | W | 3 |
| 8 | 2019-10-26 | Tennessee-Martin (150) | 10 | Southeast Missouri State (165) | 17 | Final | W | 7 |
| 9 | 2019-11-02 | Southeast Missouri State (152) | 32 | Tennessee State (227) | 13 | Final | W | 19 |
| 10 | 2019-11-09 | Eastern Kentucky (192) | 31 | Southeast Missouri State (149) | 38 | Final | W | 7 |
| 11 | 2019-11-16 | Southeast Missouri State (148) | 26 | Eastern Illinois (244) | 12 | Final | W | 14 |
| 12 | 2019-11-23 | Murray State (215) | 24 | Southeast Missouri State (147) | 31 | Final | W | 7 |
| 13 | 2019-11-30 | Illinois State (155) | 24 | Southeast Missouri State (145) | 6 | Final | L | -18 |