Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2019-08-29 | Southern Illinois (212) | 26 | Southeast Missouri State (152) | 44 | Final | L | -18 |
| 2 | 2019-09-07 | Southern Illinois (212) | 45 | Massachusetts (110) | 20 | Final | W | 25 |
| 3 | 2019-09-14 | Tennessee-Martin (223) | 14 | Southern Illinois (212) | 28 | Final | W | 14 |
| 4 | 2019-09-21 | Southern Illinois (212) | 28 | Arkansas State (73) | 41 | Final | L | -13 |
| 5 | 2019-10-05 | Southern Illinois (137) | 10 | South Dakota State (153) | 28 | Final | L | -18 |
| 6 | 2019-10-12 | Illinois State (156) | 21 | Southern Illinois (149) | 7 | Final | L | -14 |
| 7 | 2019-10-19 | Youngstown State (151) | 10 | Southern Illinois (154) | 35 | Final | W | 25 |
| 8 | 2019-10-26 | Southern Illinois (145) | 48 | South Dakota (188) | 28 | Final | W | 20 |
| 9 | 2019-11-02 | Southern Illinois (140) | 23 | Indiana State (212) | 14 | Final | W | 9 |
| 10 | 2019-11-09 | Missouri State (235) | 14 | Southern Illinois (142) | 37 | Final | W | 23 |
| 11 | 2019-11-16 | Southern Illinois (142) | 45 | Western Illinois (243) | 21 | Final | W | 24 |
| 12 | 2019-11-23 | North Dakota State (89) | 21 | Southern Illinois (140) | 7 | Final | L | -14 |