Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2019-08-29 | Eastern Illinois (219) | 10 | Chattanooga (188) | 24 | Final | L | -14 |
| 2 | 2019-09-07 | Eastern Illinois (219) | 0 | Indiana (65) | 52 | Final | L | -52 |
| 3 | 2019-09-14 | Illinois State (141) | 21 | Eastern Illinois (219) | 3 | Final | L | -18 |
| 4 | 2019-09-21 | Eastern Illinois (219) | 6 | Indiana State (154) | 16 | Final | L | -10 |
| 5 | 2019-09-28 | Tennessee Tech (150) | 40 | Eastern Illinois (244) | 29 | Final | L | -11 |
| 6 | 2019-10-05 | Eastern Illinois (243) | 17 | Murray State (201) | 24 | Final | L | -7 |
| 7 | 2019-10-12 | Jacksonville State (180) | 28 | Eastern Illinois (247) | 20 | Final | L | -8 |
| 8 | 2019-10-19 | Eastern Illinois (244) | 18 | Tennessee-Martin (150) | 27 | Final | L | -9 |
| 9 | 2019-10-26 | Eastern Kentucky (189) | 33 | Eastern Illinois (245) | 6 | Final | L | -27 |
| 10 | 2019-11-09 | Eastern Illinois (250) | 49 | Tennessee State (233) | 38 | Final | W | 11 |
| 11 | 2019-11-16 | Southeast Missouri State (148) | 26 | Eastern Illinois (244) | 12 | Final | L | -14 |
| 12 | 2019-11-23 | Eastern Illinois (246) | 7 | Austin Peay (152) | 35 | Final | L | -28 |