Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2017-09-02 | Southeast Missouri State | 16 | Kansas | 38 | Final | L | -22 |
| 2 | 2017-09-09 | Southeast Missouri State | 23 | Dayton | 25 | Final | L | -2 |
| 3 | 2017-09-16 | Southern Illinois | 35 | Southeast Missouri State | 17 | Final | L | -18 |
| 4 | 2017-09-23 | Southeast Missouri State | 16 | Eastern Illinois | 19 | Final | L | -3 |
| 5 | 2017-09-30 | Eastern Kentucky | 10 | Southeast Missouri State | 29 | Final | W | 19 |
| 6 | 2017-10-14 | Tennessee Tech | 3 | Southeast Missouri State | 31 | Final | W | 28 |
| 7 | 2017-10-21 | Southeast Missouri State | 31 | Austin Peay | 38 | Final | L | -7 |
| 8 | 2017-10-28 | Southeast Missouri State | 7 | Jacksonville State | 23 | Final | L | -16 |
| 9 | 2017-11-04 | Tennessee-Martin | 16 | Southeast Missouri State | 14 | Final | L | -2 |
| 10 | 2017-11-11 | Southeast Missouri State | 20 | Tennessee State | 23 | Final | L | -3 |
| 11 | 2017-11-18 | Murray State | 10 | Southeast Missouri State | 21 | Final | W | 11 |