Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2017-09-16 | Southern Illinois | 35 | Southeast Missouri State | 17 | Final | W | 18 |
| 2 | 2017-09-23 | Southern Illinois | 31 | Memphis | 44 | Final | L | -13 |
| 3 | 2017-09-30 | Northern Iowa | 24 | Southern Illinois | 17 | Final | L | -7 |
| 4 | 2017-10-07 | Southern Illinois | 14 | South Dakota State | 49 | Final | L | -35 |
| 5 | 2017-10-14 | Illinois State | 7 | Southern Illinois | 42 | Final | W | 35 |
| 6 | 2017-10-21 | Southern Illinois | 45 | Indiana State | 24 | Final | W | 21 |
| 7 | 2017-10-28 | Southern Illinois | 0 | South Dakota | 42 | Final | L | -42 |
| 8 | 2017-11-04 | Missouri State | 36 | Southern Illinois | 28 | Final | L | -8 |
| 9 | 2017-11-11 | Youngstown State | 28 | Southern Illinois | 20 | Final | L | -8 |
| 10 | 2017-11-18 | Southern Illinois | 14 | Western Illinois | 28 | Final | L | -14 |